Properties of the weighted log‐rank test in the design of confirmatory studies with delayed effects

Proportional hazards are a common assumption when designing confirmatory clinical trials in oncology. This assumption not only affects the analysis part but also the sample size calculation. The presence of delayed effects causes a change in the hazard ratio while the trial is ongoing since at the beginning we do not observe any difference between treatment arms, and after some unknown time point, the differences between treatment arms will start to appear. Hence, the proportional hazards assumption no longer holds, and both sample size calculation and analysis methods to be used should be reconsidered. The weighted log‐rank test allows a weighting for early, middle, and late differences through the Fleming and Harrington class of weights and is proven to be more efficient when the proportional hazards assumption does not hold. The Fleming and Harrington class of weights, along with the estimated delay, can be incorporated into the sample size calculation in order to maintain the desired power once the treatment arm differences start to appear. In this article, we explore the impact of delayed effects in group sequential and adaptive group sequential designs and make an empirical evaluation in terms of power and type‐I error rate of the of the weighted log‐rank test in a simulated scenario with fixed values of the Fleming and Harrington class of weights. We also give some practical recommendations regarding which methodology should be used in the presence of delayed effects depending on certain characteristics of the trial.     

The quantile-based flattened logistic distribution: Some properties and applications

In this paper, the quantile-based flattened logistic distribution has been studied. Some classical and quantile-based properties of the distribution have been obtained. Closed form expressions of L-moments, L-moment ratios and expectation of order statistics of the distribution have been obtained. A quantile-based analysis concerning the method of matching L-moments estimation is employed to estimate the parameters of the proposed model. We further derive the asymptotic variance–covariance matrix of the matching L-Moments estimators of the proposed model. Finally, we apply the proposed model to simulated as well as two real life datasets and compare the fit with the logistic distribution.     

Local influence in multilevel models

The authors study the local influence of observations in multilevel regression models. To this end, they perturb simultaneously the variances, responses and design matrix. To measure the local change caused by these perturbations, they use generalized Cook statistics for the fixed and random parameter estimates. Closed form local influence measures also allow them to assess the joint influence of various observations. They suggest a simple computation method and illustrate their results using two examples.     

LLSM在群体判断中的推广和应用

首先分析了对数最小二乘排序法的特点,说明它是一种值得重视的好方法;并进一步阐述了这一方法的基本原理,着重地对群体判断下求加权的综合排序向量的方法进行了严密的数学推导;提出了在加权的综合排序中权重系数确定的新見解,并举例子以解释。     

从人道主义向自然主义迈进的福克纳——读《我弥留之际》

美国南方流派的代表作家威廉·福克纳是一位实验性的作家,在他的文学生涯中,他做过多种尝试,他的早期长篇小说《我弥留之际》是其中非常重要的一次。这部作品的创作思想显示福克纳在上世纪30年代从人道主义向自然主义迈进。     

海上救助公约的发展及其主要影响

1989年通过的国际救助公约对传统的“无效果无报酬”原则所作的例外规定,引起了海运界和贸易界的极大关注,从而导致某些国际规则和国内法的修订。本文运用比较的方法对海上救助公约的发展及其对英国劳氏标准救助契约、国际共同海损理算规则和我国海商法的影响作了论述,并且提出了我国当前海商法应作修改补充的几点建议。     

抚顺天湖大桥索夹安装方法

抚顺天湖大桥是一座自锚式悬索桥，主缆材料采用钢丝绳，索夹安装前通过主缆与索夹摩阻系数试验，深入研究了高强螺栓预紧力损失的规律，获得了索夹安装的一系列控制参数；介绍了无猫道施工悬索桥使用移动平台安装索夹的方法和索夹安装时高强螺栓的施拧方案。