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1.
Stephen J. Ruberg Frank E. Harrell Jr. Margaret Gamalo-Siebers Lisa LaVange J. Jack Lee Karen Price 《The American statistician》2019,73(1):319-327
ABSTRACTThe cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making. 相似文献
2.
针对我国政府、企业和银行等金融机构共同关注的债转股问题,基于债务协商谈判思想,建立部分债务股权互换模型,计算公司证券价格,探讨了债转股对公司价值、破产概率、破产损失成本和资本结构的影响,给出了银行等债权人愿意债转股的充分条件。结果表明:在事先破产清算协议贷款下,事后全部债转股总能提高公司股权价值,但并不一定能提高债券价值。只有其协商谈判能力满足一定条件,公司债权人才愿意事后选择债转股,实现帕累托改进、提高社会福利水平。其次,在公司股东协商谈判能力的一定范围内,部分债转股能提高公司价值,其最优转股债息比例随着公司资产风险的增大而增加。再次,债转股能降低公司破产风险和破产损失成本,但同时也提高了债券风险溢价。最后,随着股东谈判能力增强,最优协商转股债务比例、杠杆率都减少,而债券风险溢价增大。本文所得结果对我国政府、企业和银行如何实施债转股提供理论参考和实践指导。 相似文献
3.
Aggressive behavior in pet dogs is a serious problem for dog owners across the globe, with bite injuries representing a serious risk to both people and other dogs. The effective management of aggressive behavior in dogs represents a challenging and controversial issue. Although positive reinforcement training methods are now considered to be the most effective and humane technique to manage the risk of aggression, punishment‐based methods continue to be used. Unfortunately, there has been little scientific study into the various factors influencing whether dog owners choose to use positive reinforcement techniques to manage aggression in their dogs. As such, current understanding of how best to encourage and support dog owners to use these methods remains extremely limited. This article uses a survey methodology based on protection motivation theory (PMT) to investigate the factors that influence owner use of positive reinforcement methods to manage aggressive behavior, in an attempt to understand potential barriers and drivers of use. In addition, the article provides an initial exploration of the potential role of wider psychological factors, including owner emotional state, social influence, and cognitive bias. Findings show that the perceived efficacy of positive reinforcement methods and the perceived ability of owners to effectively implement the technique are both key factors predicting future intentions and current reported use. Future interventions should focus on enhancing owner confidence in the effective use of positive reinforcement techniques across multiple scenarios, as well as helping owners manage their own emotional responses when they encounter challenging situations and setbacks. 相似文献
4.
David R. Bickel 《统计学通讯:理论与方法》2020,49(11):2703-2712
AbstractConfidence sets, p values, maximum likelihood estimates, and other results of non-Bayesian statistical methods may be adjusted to favor sampling distributions that are simple compared to others in the parametric family. The adjustments are derived from a prior likelihood function previously used to adjust posterior distributions. 相似文献
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6.
Keisuke Himoto 《Risk analysis》2020,40(6):1124-1138
Post-earthquake fires are high-consequence events with extensive damage potential. They are also low-frequency events, so their nature remains underinvestigated. One difficulty in modeling post-earthquake ignition probabilities is reducing the model uncertainty attributed to the scarce source data. The data scarcity problem has been resolved by pooling the data indiscriminately collected from multiple earthquakes. However, this approach neglects the inter-earthquake heterogeneity in the regional and seasonal characteristics, which is indispensable for risk assessment of future post-earthquake fires. Thus, the present study analyzes the post-earthquake ignition probabilities of five major earthquakes in Japan from 1995 to 2016 (1995 Kobe, 2003 Tokachi-oki, 2004 Niigata–Chuetsu, 2011 Tohoku, and 2016 Kumamoto earthquakes) by a hierarchical Bayesian approach. As the ignition causes of earthquakes share a certain commonality, common prior distributions were assigned to the parameters, and samples were drawn from the target posterior distribution of the parameters by a Markov chain Monte Carlo simulation. The results of the hierarchical model were comparatively analyzed with those of pooled and independent models. Although the pooled and hierarchical models were both robust in comparison with the independent model, the pooled model underestimated the ignition probabilities of earthquakes with few data samples. Among the tested models, the hierarchical model was least affected by the source-to-source variability in the data. The heterogeneity of post-earthquake ignitions with different regional and seasonal characteristics has long been desired in the modeling of post-earthquake ignition probabilities but has not been properly considered in the existing approaches. The presented hierarchical Bayesian approach provides a systematic and rational framework to effectively cope with this problem, which consequently enhances the statistical reliability and stability of estimating post-earthquake ignition probabilities. 相似文献
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8.
<共产党宣言>所开创的伟大事业,在中国共产党的继承、发展和创新下,取得了举世瞩目的成就.十六大是我党在新时期召开的一次极为重要的会议,会议通过的报告从多方面继承和发展了<共产党宣言>的基本观点,是当今中国社会主义建设的纲领性文件,是新世纪初中国社会主义建设的<共产党宣言>. 相似文献
9.
天波 《广西师范学院学报(哲学社会科学版)》2002,23(2):62-65
乾隆三十三年 ,纪昀因为“漏言”被谪贬至西域乌鲁木齐。与古代其他谪贬文人所不同的是 ,他并未完全沉浸于穷愁怨艾的情绪中 ,而是以积极乐观的人生态度面对现实。他的《乌鲁木齐杂诗》及《阅微草堂笔记》多方面地展示了西域的风土人情。但两者在内容及视角上有所不同 ,《乌鲁木齐杂诗》以丰富见长 ,但多粉饰之意 ;《阅微草堂笔记》以深刻取胜 ,真实而颇见其洞察力 相似文献
10.
以英语学习中出现的正向迁移和负向迁移为例证,分析汉语对学习英语所产生的影响,而重点论述以汉语为母语的思维定势对英语学习产生的负向迁移影响,并提出了如何排除母语干扰的若干意见。 相似文献