Non-ignorable missing covariate data in survival analysis: a case-study of an International Breast Cancer Study Group trial

Summary.  Non-ignorable missing data, a serious problem in both clinical trials and observational studies, can lead to biased inferences. Quality-of-life measures have become increasingly popular in clinical trials. However, these measures are often incompletely observed, and investigators may suspect that missing quality-of-life data are likely to be non-ignorable. Although several recent references have addressed missing covariates in survival analysis, they all required the assumption that missingness is at random or that all covariates are discrete. We present a method for estimating the parameters in the Cox proportional hazards model when missing covariates may be non-ignorable and continuous or discrete. Our method is useful in reducing the bias and improving efficiency in the presence of missing data. The methodology clearly specifies assumptions about the missing data mechanism and, through sensitivity analysis, helps investigators to understand the potential effect of missing data on study results.     

Factor analysis for ranked data with application to a job selection attitude survey

Summary.  Factor analysis is a powerful tool to identify the common characteristics among a set of variables that are measured on a continuous scale. In the context of factor analysis for non-continuous-type data, most applications are restricted to item response data only. We extend the factor model to accommodate ranked data. The Monte Carlo expectation–maximization algorithm is used for parameter estimation at which the E-step is implemented via the Gibbs sampler. An analysis based on both complete and incomplete ranked data (e.g. rank the top q out of k items) is considered. Estimation of the factor scores is also discussed. The method proposed is applied to analyse a set of incomplete ranked data that were obtained from a survey that was carried out in GuangZhou, a major city in mainland China, to investigate the factors affecting people's attitude towards choosing jobs.     

Random variate transformations in the Gibbs sampler: issues of efficiency and convergence

In the non-conjugate Gibbs sampler, the required sampling from the full conditional densities needs the adoption of black-box sampling methods. Recent suggestions include rejection sampling, adaptive rejection sampling, generalized ratio of uniforms, and the Griddy-Gibbs sampler. This paper describes a general idea based on variate transformations which can be tailored in all the above methods and increase the Gibbs sampler efficiency. Moreover, a simple technique to assess convergence is suggested and illustrative examples are presented.     

Bayesian analysis of outlier problems using divergence measures

A Bayesian approach is presented for detecting influential observations using general divergence measures on the posterior distributions. A sampling-based approach using a Gibbs or Metropolis-within-Gibbs method is used to compute the posterior divergence measures. Four specific measures are proposed, which convey the effects of a single observation or covariate on the posterior. The technique is applied to a generalized linear model with binary response data, an overdispersed model and a nonlinear model. An asymptotic approximation using Laplace method to obtain the posterior divergence is also briefly discussed.     

基于MCMC稳态模拟的贝叶斯经验费率厘定信用模型

B黨lmann-Straub model is one of the most famous applications of the Bayesian method for the experience rate making.However,by the traditional B黨lmann-Straub model one cannot get the unbiased posterior estimation of the parameters when there is not sufficient prior information for the structural parameters;What's more,the difficult of computing high dimension numeration limits the application of Bayesian method.This paper introduces the Markov chain Monte Carlo simulaton method based on the Gibbs sampling after analyzing the structure of the B黨lmann-Straub model and sets up the Bayesian credibility model for estimating the predictive risk premium.Also by using the results of the numeration analysis,this paper proves that from this model one can get the posterior distributions of the parameters dynamically and the posterior estimation of the censoring parameters in the situation that exists unknown parameters,as well as improve the precision of the numeration,which can be helpful to find the heterogeneity of the premium.     

Nonparametric Bayesian inference for multivariate density functions using Feller priors

Multivariate density estimation plays an important role in investigating the mechanism of high-dimensional data. This article describes a nonparametric Bayesian approach to the estimation of multivariate densities. A general procedure is proposed for constructing Feller priors for multivariate densities and their theoretical properties as nonparametric priors are established. A blocked Gibbs sampling algorithm is devised to sample from the posterior of the multivariate density. A simulation study is conducted to evaluate the performance of the procedure.     

Bias correction for parameter estimates of spatial point process models

When a spatial point process model is fitted to spatial point pattern data using standard software, the parameter estimates are typically biased. Contrary to folklore, the bias does not reflect weaknesses of the underlying mathematical methods, but is mainly due to the effects of discretization of the spatial domain. We investigate two approaches to correcting the bias: a Newton–Raphson-type correction and Richardson extrapolation. In simulation experiments, Richardson extrapolation performs best.     

Bayesian Estimation and Model Choice in Item Response Models

Item response models are essential tools for analyzing results from many educational and psychological tests. Such models are used to quantify the probability of correct response as a function of unobserved examinee ability and other parameters explaining the difficulty and the discriminatory power of the questions in the test. Some of these models also incorporate a threshold parameter for the probability of the correct response to account for the effect of guessing the correct answer in multiple choice type tests. In this article we consider fitting of such models using the Gibbs sampler. A data augmentation method to analyze a normal-ogive model incorporating a threshold guessing parameter is introduced and compared with a Metropolis-Hastings sampling method. The proposed method is an order of magnitude more efficient than the existing method. Another objective of this paper is to develop Bayesian model choice techniques for model discrimination. A predictive approach based on a variant of the Bayes factor is used and compared with another decision theoretic method which minimizes an expected loss function on the predictive space. A classical model choice technique based on a modified likelihood ratio test statistic is shown as one component of the second criterion. As a consequence the Bayesian methods proposed in this paper are contrasted with the classical approach based on the likelihood ratio test. Several examples are given to illustrate the methods.     

Bayesian inference under progressive type-I interval censoring

Bayesian estimation for population parameter under progressive type-I interval censoring is studied via Markov Chain Monte Carlo (MCMC) simulation. Two competitive statistical models, generalized exponential and Weibull distributions for modeling a real data set containing 112 patients with plasma cell myeloma, are studied for illustration. In model selection, a novel Bayesian procedure which involves a mixture model is proposed. Then the mix proportion is estimated through MCMC and used as the model selection criterion.     

Bayesian ratemaking under Dirichlet process mixtures

Experience ratemaking plays a crucial role in general insurance in determining future premiums of individuals in a portfolio by assessing observed claims from the whole portfolio. This paper investigates this problem in which claims can be modeled by certain parametric family of distributions. The Dirichlet process mixtures are employed to model the distributions of the parameters so as to make two advantages: to produce exact Bayesian experience premiums for a class of premium principles generated from generic error functions and, at the same time, provide robust and flexible ways to avoid possible bias caused by traditionally used priors such as non informative priors or conjugate priors. In this paper, the Bayesian experience ratemaking under Dirichlet process mixture models are investigated and due to the lack of analytical forms of the conditional expectations of the quantities concerned, the Gibbs sampling schemes are designed for the purpose of approximations.