Assessing accuracy of a continuous screening test in the presence of verification bias

Summary.  In studies to assess the accuracy of a screening test, often definitive disease assessment is too invasive or expensive to be ascertained on all the study subjects. Although it may be more ethical or cost effective to ascertain the true disease status with a higher rate in study subjects where the screening test or additional information is suggestive of disease, estimates of accuracy can be biased in a study with such a design. This bias is known as verification bias. Verification bias correction methods that accommodate screening tests with binary or ordinal responses have been developed; however, no verification bias correction methods exist for tests with continuous results. We propose and compare imputation and reweighting bias-corrected estimators of true and false positive rates, receiver operating characteristic curves and area under the receiver operating characteristic curve for continuous tests. Distribution theory and simulation studies are used to compare the proposed estimators with respect to bias, relative efficiency and robustness to model misspecification. The bias correction estimators proposed are applied to data from a study of screening tests for neonatal hearing loss.     

亚里士多德的"德性就是中道"思想解读--读《尼各马科伦理学》有感

亚里士多德的《尼各马科伦理学》是其伦理学思想的代表作,书中阐述的重要内容之一:“德性就是中道”,具有丰富的内涵,体现了与德性相关的选择性、实践理性以及与社会性生活密切相关等特点。这些对当代道德教育仍有一定的启迪意义。     

Record-breaking data: a parametric comparison of the inverse-sampling and the random-sampling schemes

In many industrial quality control experiments and destructive stress testing, the only available data are successive minima (or maxima)i.e., record-breaking data. There are two sampling schemes used to collect record-breaking data: random sampling and inverse sampling. For random sampling, the total sample size is predetermined and the number of records is a random variable while in inverse-sampling the number of records to be observed is predetermined; thus the sample size is a random variable. The purpose of this papper is to determinevia simulations, which of the two schemes, if any, is more efficient. Since the two schemes are equivalent asymptotically, the simulations were carried out for small to moderate sized record-breaking samples. Simulated biases and mean square errors of the maximum likelihood estimators of the parameters using the two sampling schemes were compared. In general, it was found that if the estimators were well behaved, then there was no significant difference between the mean square errors of the estimates for the two schemes. However, for certain distributions described by both a shape and a scale parameter, random sampling led to estimators that were inconsistent. On the other hand, the estimated obtained from inverse sampling were always consistent. Moreover, for moderated sized record-breaking samples, the total sample size that needs to be observed is smaller for inverse sampling than for random sampling.     

A new estimator of proportion with a linear function using data from two-decks randomized response model

A new estimator for estimating the proportion of a potentially sensitive attribute in survey sampling has been introduced by solving a linear equation. The proposed estimator has been compared with the estimator proposed by Odumade and Singh (2009) with equal protection to all of the respondents. The asymptotic properties of the proposed estimator are investigated through exact numerical illustrations for different choices of parameters. A non randomized response approach has been suggested. A scope for further research has also been pointed out.     

Estimation of Mode Using Two-phase Sampling

In this article, we consider the problem of estimation of mode using two-phase sampling. Ratio- and difference-type estimators in two-phase sampling are proposed. The asymptotic properties of the proposed estimators are studied analytically as well as empirically for different situations for the given cost of surveys. The use of two-phase sampling has been found to be cost saving design while estimating mode by making a proper use of auxiliary information.     

Quasi-minimax estimation in the partial linear model

This article discusses the minimax estimator in partial linear model y = Zβ + f + ε under ellipsoidal restrictions on the parameter space and quadratic loss function. The superiority of the minimax estimator over the two-step estimator is studied in the mean squared error matrix criterion.     

Classical estimation of hazard rate and mean residual life functions of Pareto distribution

Abstract

In this paper we find the maximum likelihood estimates (MLEs) of hazard rate and mean residual life functions (MRLF) of Pareto distribution, their asymptotic non degenerate distribution, exact distribution and moments. We also discuss the uniformly minimum variance unbiased estimate (UMVUE) of hazard rate function and MRLF. Finally, two numerical examples with simulated data and real data set, are presented to illustrate the proposed estimates.     

Probability Generating Function Based Jeffrey's Divergence for Statistical Inference

Statistical inference procedures based on transforms such as characteristic function and probability generating function have been examined by many researchers because they are much simpler than probability density functions. Here, a probability generating function based Jeffrey's divergence measure is proposed for parameter estimation and goodness-of-fit test. Being a member of the M-estimators, the proposed estimator is consistent. Also, the proposed goodness-of-fit test has good statistical power. The proposed divergence measure shows improved performance over existing probability generating function based measures. Real data examples are given to illustrate the proposed parameter estimation method and goodness-of-fit test.     

An Improved Distribution-free EWMA Mean Chart

Control charts are effective tools for signal detection in both manufacturing processes and service processes. Much service data come from a process with variables having nonnormal or unknown distributions. The commonly used Shewhart variable control charts, which depend heavily on the normality assumption, should not be properly used here. In this article, we propose an improved asymmetric EWMA mean chart based on a simple statistic to monitor process mean shift. We explored the sampling properties of the new monitoring statistic and calculated the average run lengths of the proposed asymmetric EWMA mean chart. We recommend the proposed improved asymmetric EWMA mean chart because the average run lengths of the modified charts are more accurate and reasonable than those of the five existed mean charts. A numerical example of service times with a right skewed distribution from a service system of a bank branch is used to illustrate the application of the improved asymmetric EWMA mean chart and to compare it with the five existing mean charts. The proposed chart showed better detection performance than those of the five existing mean charts in monitoring and detecting shifts in the process mean.     

中庸与中道思想比较研究

中国的孔子和古希腊的亚里士多德在相似的历史时期提出了共同的中庸和中道思想,对世界文化思想的发展均产生了重大影响.在我们建设全面小康、构建和谐社会的今天,有必要从其产生的历史背景、含义、内容、实现途径以及各自对后世的影响这些方面对这一人类思想史上的优秀成果进行剖析,以充分吸收这一思想的精华,古为今用,洋为中用.