Examples of the use of an equivalence theorem in constructing optimum experimental designs for random-effects nonlinear regression models

The problem considered is that of finding an optimum measurement schedule to estimate population parameters in a nonlinear model when the patient effects are random. The paper presents examples of the use of sensitivity functions, derived from the General Equivalence Theorem for D-optimality, in the construction of optimum population designs for such schedules. With independent observations, the theorem applies to the potential inclusion of a single observation. However, in population designs the observations are correlated and the theorem applies to the inclusion of an additional measurement schedule. In one example, three groups of patients of differing size are subject to distinct schedules. Numerical, as opposed to analytical, calculation of the sensitivity function is advocated. The required covariances of the observations are found by simulation.     

Efficient designs based on orthogonal arrays of type I and type II for experiments using units ordered over time or space

For a wide variety of applications, experiments are based on units ordered over time or space. Models for these experiments generally may include one or more of: correlations, systematic trends, carryover effects and interference effects. Since the standard optimal block designs may not be efficient in these situations, orthogonal arrays of type I and type II, which were introduced in 1961 by C.R. Rao [Combinatorial arrangements analogous to orthogonal arrays, Sankhya A 23 (1961) 283–286], have been recently used to construct optimal and efficient designs for many of these experiments. Results in this area are unified and the salient features are outlined.     

几组复合麻醉方法对犬麻醉效果比较

复方846、静松灵/氯胺酮、氯丙嗪/氯胺酮、氯丙嗪/乙醚、氯丙嗪/静松灵,均可使犬获得一定时间的麻醉效果。通过麻醉前、后体温(T℃)、呼吸(R),脉搏(P),镇痛反应,麻醉维持时间的检测;通过麻醉后手术安静顺利情况;从伤口愈合情况,以及术前、术后3天、7天白细胞、淋巴细胞、T淋巴细胞的变化表明:几组药物作用于犬后,体温间差异不显著(P>0.05),呼吸、脉搏部分呈显著性变化(P>0.05),各组术前、术后3天、7天的白细胞、淋巴细胞、T淋巴细胞变化组间差异不显著(P>0.05)。镇痛作用以复方846为好,其次为静松灵/氯胺酮、氯丙嗪/静松灵、氯丙嗪/氯胺酮、氯丙嗪/乙醚;麻醉维持时间复方846最长(133.70±9.66),其次为静松灵/氯胺酮(89±9.9);从手术安静顺利情况看,复方846、静松灵/氯胺酮优于其它组;从伤口愈合情况看,静松灵/氯胺酮优于其它组。综合比较:复方846、静松灵/氯胺酮用于大的临床麻醉,效果确实。     

An access network design problem with end-to-end QoS constraints

In this paper, we present an access network design problem with end-to-end quality of service (QoS) requirement. The problem can be conceptualized as a two-level hierarchical location-allocation problem on the tree topology with nonlinear side constraints. The objective function of the nonlinear mixed integer programming model minimizes the total cost of switch and fiber cable, while satisfying demand within the prescribed level of QoS. By exploiting the inherent structure of the nonlinear QoS constraints, we develop linearization techniques for finding an optimal solution. Also, we devise an effective exact optimal algorithm within the context of disjunctive constraint generation. We present promising computational results that demonstrate the effectiveness of the proposed solution procedure.     

Mixed integer (0–1) fractional programming for decision support in paper production industry

This paper presents an effective and efficient method for solving a special class of mixed integer fractional programming (FP) problems. We take a classical reformulation approach for continuous FP as a starting point and extend it for solving a more general class of mixed integer (0–1) fractional programming problems.To stress the practical relevance of the research we focus on a real-life application in paper production industry. The constantly advancing physical knowledge of large scale pulp and paper production did have a substantial impact on an existing DSS in which mixed integer (0–1) fractional programming is introduced. We show that the motivation to solve a real-life fractional programming problem can provide the basis for a new approach in a new context that has an added value of its own, even outside the given application area. We describe the main characteristics of the DSS, the necessity to develop a non-iterative solution procedure and demonstrate both the effectiveness and efficiency of the proposed approach from practical data sets.     

Staff rostering in call centers providing employee transportation

We address the staff rostering problem in call centers with the goal of balancing operational cost, agent satisfaction and customer service objectives. In metropolitan cities such as Istanbul and Mumbai, call centers provide the transportation of their staff so that shuttle costs constitute a significant part of the operational costs. We develop a mixed integer programming model that incorporates the shuttle requirements at the beginning and end of the shifts into the agent-shift assignment decisions, while considering the skill sets of the agents, and other constraints due to workforce regulations and agent preferences. We analyze model solutions for a banking call center under various management priorities to understand the interactions among the conflicting objectives. We show that considering transportation costs as well as agent preferences in agent-shift assignments provides significant benefits in terms of both cost savings and employee satisfaction.     

A latent variable model for analyzing mixed longitudinal (k,l)-inflated count and ordinal responses

A random effects model for analyzing mixed longitudinal count and ordinal data is presented where the count response is inflated in two points (k and l) and an (k,l)-Inflated Power series distribution is used as its distribution. A full likelihood-based approach is used to obtain maximum likelihood estimates of parameters of the model. For data with non-ignorable missing values models with probit model for missing mechanism are used.The dependence between longitudinal sequences of responses and inflation parameters are investigated using a random effects approach. Also, to investigate the correlation between mixed ordinal and count responses of each individuals at each time, a shared random effect is used. In order to assess the performance of the model, a simulation study is performed for a case that the count response has (k,l)-Inflated Binomial distribution. Performance comparisons of count-ordinal random effect model, Zero-Inflated ordinal random effects model and (k,l)-Inflated ordinal random effects model are also given. The model is applied to a real social data set from the first two waves of the national longitudinal study of adolescent to adult health (Add Health study). In this data set, the joint responses are the number of days in a month that each individual smoked as the count response and the general health condition of each individual as the ordinal response. For the count response there is incidence of excess values of 0 and 30.     

Latin hypercube sampling with multidimensional uniformity

Complex models can only be realized a limited number of times due to large computational requirements. Methods exist for generating input parameters for model realizations including Monte Carlo simulation (MCS) and Latin hypercube sampling (LHS). Recent algorithms such as maximinLHS seek to maximize the minimum distance between model inputs in the multivariate space. A novel extension of Latin hypercube sampling (LHSMDU) for multivariate models is developed here that increases the multidimensional uniformity of the input parameters through sequential realization elimination. Correlations are considered in the LHSMDU sampling matrix using a Cholesky decomposition of the correlation matrix. Computer code implementing the proposed algorithm supplements this article. A simulation study comparing MCS, LHS, maximinLHS and LHSMDU demonstrates that increased multidimensional uniformity can significantly improve realization efficiency and that LHSMDU is effective for large multivariate problems.     

金融资产的动态非线性相关:一个新的模型

基于Kendall’sτ秩相关系数的优越性和定义,本文提出了新的具有明确经济意义的动态条件相关copula模型,将常用的Gaussian、Clayton和Gumbel函数统一根据该演化方程实现动态化,构造出三种Kendall’sτ动态条件相关copula模型,可用于刻画不同的相关模式。这些模型不仅参数少、容易估计,避免了现有动态条件相关copula模型构建方法各异导致的在实证中不利于比较的缺点,而且能够进行多步向前预测,有效地减少了进行样本外预测时的计算量,从而为刻画时变、非线性、非对称性和尾部相关等复杂的动态相关模式提供了新方法。     

Assessing the performance of variational methods for mixed logistic regression models

We present a variational estimation method for the mixed logistic regression model. The method is based on a lower bound approximation of the logistic function [Jaakkola, J.S. and Jordan, M.I., 2000, Bayesian parameter estimation via variational methods. Statistics & Computing, 10, 25–37.]. Based on the approximation, an EM algorithm can be derived that results in a considerable simplification of the maximization problem in that it does not require the numerical evaluation of integrals over the random effects. We assess the performance of the variational method for the mixed logistic regression model in a simulation study and an empirical data example, and compare it to Laplace's method. The results indicate that the variational method is a viable choice for estimating the fixed effects of the mixed logistic regression model under the condition that the number of outcomes within each cluster is sufficiently high.