Examples of the use of an equivalence theorem in constructing optimum experimental designs for random-effects nonlinear regression models

The problem considered is that of finding an optimum measurement schedule to estimate population parameters in a nonlinear model when the patient effects are random. The paper presents examples of the use of sensitivity functions, derived from the General Equivalence Theorem for D-optimality, in the construction of optimum population designs for such schedules. With independent observations, the theorem applies to the potential inclusion of a single observation. However, in population designs the observations are correlated and the theorem applies to the inclusion of an additional measurement schedule. In one example, three groups of patients of differing size are subject to distinct schedules. Numerical, as opposed to analytical, calculation of the sensitivity function is advocated. The required covariances of the observations are found by simulation.     

Variance (Non) Causality in Multivariate GARCH

This paper extends the current literature on the variance-causality topic providing the coefficient restrictions ensuring variance noncausality within multivariate GARCH models with in-mean effects. Furthermore, this paper presents a new multivariate model, the exponential causality GARCH. By the introduction of a multiplicative causality impact function, the variance causality effects becomes directly interpretable and can therefore be used to detect both the existence of causality and its direction; notably, the proposed model allows for increasing and decreasing variance effects. An empirical application evidences negative causality effects between returns and volume of an Italian stock market index future contract.     

Distributions generated by perturbation of symmetry with emphasis on a multivariate skew t-distribution

Summary . A fairly general procedure is studied to perturb a multivariate density satisfying a weak form of multivariate symmetry, and to generate a whole set of non-symmetric densities. The approach is sufficiently general to encompass some recent proposals in the literature, variously related to the skew normal distribution. The special case of skew elliptical densities is examined in detail, establishing connections with existing similar work. The final part of the paper specializes further to a form of multivariate skew t -density. Likelihood inference for this distribution is examined, and it is illustrated with numerical examples.     

Multivariate outlier detection in incomplete survey data: the epidemic algorithm and transformed rank correlations

Summary.  As a part of the EUREDIT project new methods to detect multivariate outliers in incomplete survey data have been developed. These methods are the first to work with sampling weights and to be able to cope with missing values. Two of these methods are presented here. The epidemic algorithm simulates the propagation of a disease through a population and uses extreme infection times to find outlying observations. Transformed rank correlations are robust estimates of the centre and the scatter of the data. They use a geometric transformation that is based on the rank correlation matrix. The estimates are used to define a Mahalanobis distance that reveals outliers. The two methods are applied to a small data set and to one of the evaluation data sets of the EUREDIT project.     

Bayesian networks for imputation

Summary.  Bayesian networks are particularly useful for dealing with high dimensional statistical problems. They allow a reduction in the complexity of the phenomenon under study by representing joint relationships between a set of variables through conditional relationships between subsets of these variables. Following Thibaudeau and Winkler we use Bayesian networks for imputing missing values. This method is introduced to deal with the problem of the consistency of imputed values: preservation of statistical relationships between variables ( statistical consistency ) and preservation of logical constraints in data ( logical consistency ). We perform some experiments on a subset of anonymous individual records from the 1991 UK population census.     

Missing data and forecasting in multivariate time series: An application of the common components dynamic linear model

Summary The paper deals with missing data and forecasting problems in multivariate time series making use of the Common Components Dynamic Linear Model (DLMCC), presented in Quintana (1985), and West and Harrison (1989). Some results are presented and discussed: exploiting the correlation between series, estimated by the DLMCC, the paper shows as it is possible to update state vector posterior distributions for the unobserved series. This is realized on the base of the updating of the observed series state vectors, for which the usual Kalman filter equations can be applied. An application concerning some Italian private consumption series provides an example of the model capabilities.     

On a system of nonhomogeneous components sharing a common frailty

The components of a reliability system subjected to a common random environment usually have dependent lifetimes. This paper studies the stochastic properties of such a system with lifetimes of the components following multivariate frailty models and multivariate mixed proportional reversed hazard rate (PRHR) models, respectively. Through doing stochastic comparison, we devote to throwing a new light on how the random environment affects the number of working components of a reliability system and on assessing the performance of a k-out-of-n system.     

New calibration estimator based on two auxiliary variables in stratified sampling

In recent years, calibration estimation has become an important field of research in survey sampling. This paper proposes a new calibration estimator for the population mean in the presence of two auxiliary variables in stratified sampling. The theory of new calibration estimator is given and optimum calibration weights are derived. A simulation study is carried out to performance of the proposed calibration estimator over other existing calibration estimators. The results reveal that the proposed calibration estimators are more efficient than other existing calibration estimators in stratified sampling.     

Optimal designs for multivariate logistic mixed models with longitudinal data

This paper considers the optimal design problem for multivariate mixed-effects logistic models with longitudinal data. A decomposition method of the binary outcome and the penalized quasi-likelihood are used to obtain the information matrix. The D-optimality criterion based on the approximate information matrix is minimized under different cost constraints. The results show that the autocorrelation coefficient plays a significant role in the design. To overcome the dependence of the D-optimal designs on the unknown fixed-effects parameters, the Bayesian D-optimality criterion is proposed. The relative efficiencies of designs reveal that both the cost ratio and autocorrelation coefficient play an important role in the optimal designs.