An Empirical Comparison of Estimating Methods for the Ramberg–Osgood EIV Model

The standard tensile test is one of the most frequent tools performed for the evaluation of mechanical properties of metals. An empirical model proposed by Ramberg and Osgood fits the tensile test data using a nonlinear model for the strain in terms of the stress. It is an Error-In-Variables (EIV) model because of the uncertainty affecting both strain and stress measurement instruments. The SIMEX, a simulation-based method for the estimation of model parameters, is powerful in order to reduce bias due to the measurement error in EIV models. The plan of this article is the following. In Sec. 2, we introduce the Ramberg–Osgood model and another reparametrization according to different assumptions on the independent variable. In Sec. 3, there is a summary of SIMEX method for the case at hand. Section 4 is a comparison between SIMEX and others estimating methods in order to highlight the peculiarities of the different approaches. In the last section, there are some concluding remarks.     

Approximate estimations in capture–recapture model with heteroscedastic measurement errors

In a capture–recapture experiment, the number of measurements for individual covariates usually equals the number of captures. This creates a heteroscedastic measurement error problem and the usual surrogate condition does not hold in the context of a measurement error model. This study adopts a small measurement error assumption to approximate the conventional estimating functions and the population size estimator. This study also investigates the biases of the resulting estimators. In addition, modifications for two common approximation methods, regression calibration and simulation extrapolation, to accommodate heteroscedastic measurement error are also discussed. These estimation methods are examined through simulations and illustrated by analysing a capture–recapture data set.     

Regression analysis of interval-censored failure time data with cured subgroup and mismeasured covariates

Abstract

Failure time data occur in many areas and also in various forms and in particular, many authors have discussed regression analysis of failure time data in the presence of interval censoring, a cured subgroup or mismeasured covariates. However, it does not seem to exist an established procedure that can deal with all three issues together. Corresponding to this, we propose a sieve maximum likelihood estimation procedure that takes into account all three issues with the use of the SIMEX algorithm. The asymptotic properties of the proposed estimators are established, and an extensive simulation study is also conducted and suggests that the proposed method works well for practical situations.     

Effect of assay measurement error on parameter estimation in concentration–QTc interval modeling

Linear mixed‐effects models (LMEMs) of concentration–double‐delta QTc intervals (QTc intervals corrected for placebo and baseline effects) assume that the concentration measurement error is negligible, which is an incorrect assumption. Previous studies have shown in linear models that independent variable error can attenuate the slope estimate with a corresponding increase in the intercept. Monte Carlo simulation was used to examine the impact of assay measurement error (AME) on the parameter estimates of an LMEM and nonlinear MEM (NMEM) concentration–ddQTc interval model from a ‘typical’ thorough QT study. For the LMEM, the type I error rate was unaffected by assay measurement error. Significant slope attenuation ( > 10%) occurred when the AME exceeded > 40% independent of the sample size. Increasing AME also decreased the between‐subject variance of the slope, increased the residual variance, and had no effect on the between‐subject variance of the intercept. For a typical analytical assay having an assay measurement error of less than 15%, the relative bias in the estimates of the model parameters and variance components was less than 15% in all cases. The NMEM appeared to be more robust to AME error as most parameters were unaffected by measurement error. Monte Carlo simulation was then used to determine whether the simulation–extrapolation method of parameter bias correction could be applied to cases of large AME in LMEMs. For analytical assays with large AME ( > 30%), the simulation–extrapolation method could correct biased model parameter estimates to near‐unbiased levels. Copyright © 2013 John Wiley & Sons, Ltd.     

Statistical inferences for single-index models with measurement errors

An important factor in house prices is its location. However, measurement errors arise frequently in the process of observing variables such as the latitude and longitude of the house. The single-index models with measurement errors are used to study the relationship between house location and house price. We obtain the estimators by a SIMEX method based on the local linear method and the estimating equation. To test the significance of the index coefficient and the linearity of the link function, we establish the generalized likelihood ratio (GLR) tests for the models. We demonstrate that the asymptotic null distributions of the established GLR tests follow χ2-distributions which are independent of nuisance parameters or functions. Finally, two simulated examples and a real estate valuation data set are given to illustrate the effect of GLR tests.     

Statistical estimation for a partially linear single-index model with errors in all variables

This article considers partially linear single-index models with errors in all variables. By using the Pseudo ? θ method (Liang, Härdle, and Carroll 1999), local linear regression and simulation-extrapolation (SIMEX) technique (Cook and Stefanski 1994), we propose an efficient methodology to estimate the current model. Under certain conditions the asymptotic properties of proposed estimators are obtained. Some simulation experiments and an application are conducted to illustrate our proposed method.     

SIMEX method for censored quantile regression with measurement error

Censored quantile regression serves as an important supplement to the Cox proportional hazards model in survival analysis. In addition to being exposed to censoring, some covariates may subject to measurement error. This leads to substantially biased estimate without taking this error into account. The SIMulation-EXtrapolation (SIMEX) method is an effective tool to handle the measurement error issue. We extend the SIMEX approach to the censored quantile regression with covariate measurement error. The algorithm is assessed via extensive simulations. A lung cancer study is analyzed to verify the validation of the proposed method.     

Varying-coefficient single-index measurement error model

This paper proposes a varying-coefficient single-index measurement error model, which consists of measurement error in the index covariates. We combine the simulation-extrapolation technique, the local linear regression and the weighted least-squares method to estimate the unknowns of the current model, and develop the asymptotic properties of the resulting estimators under some conditions. A simulation study is conducted to evaluate the proposed methodology, and a real example is also studied to illustrate our given methodology.     

On correcting measurement error in the persistence rate estimator

In the field of education, it is often of great interest to estimate the percentage of students who start out in the top test quantile at time 1 and who remain there at time 2, which is termed as “persistence rate,” to measure the students’ academic growth. One common difficulty is that students’ performance may be subject to measurement errors. We therefore considered a correlation calibration method and the simulation–extrapolation (SIMEX) method for correcting the measurement errors. Simulation studies are presented to compare various measurement error correction methods in estimating the persistence rate.