On Rao score and PearsonX 2 statistics in generalized linear models

The identity of the Rao score and PearsonX ² statistics is well known in the areas where the latter was first introduced: goodness-of-fit in contingency tables and binary responses. We show in this paper that the same identity holds when the two statistics are used for testing goodness-of-fit of Generalized Linear Models. We also highlight the connections that exist between the two statistics when they are used for the comparison of nested models. Finally, we discuss some merits of these unifying results. Work financially supported by cofin. MIUR grants 2000 and 2002.     

Which Wald statistic? Choosing a parameterization of the Wald statistic to maximize power in k-sample generalized estimating equations

The Wald statistic is known to vary under reparameterization. This raises the question: which parameterization should be chosen, in order to optimize power of the Wald statistic? We specifically consider k-sample tests of generalized linear models (GLMs) and generalized estimating equations (GEEs) in which the alternative hypothesis contains only two parameters. An example is presented in which such an alternative hypothesis is of interest. Amongst a general class of parameterizations, we find the parameterization that maximizes power via analysis of the non-centrality parameter, and show how the effect on power of reparameterization depends on sampling design and the differences in variance across samples. There is no single parameterization with optimal power across all alternatives. The Wald statistic commonly used under the canonical parameterization is optimal in some instances but it performs very poorly in others. We demonstrate results by example and by simulation, and describe their implications for likelihood ratio statistics and score statistics. We conclude that due to poor power properties, the routine use of score statistics and Wald statistics under the canonical parameterization for GEEs is a questionable practice.     

Notes on Interval Estimation of Odds Ratio in Matched Pairs under Stratified Sampling

We develop four asymptotic interval estimators and one exact interval estimator for the odds ratio (OR) under stratified random sampling with matched pairs. We apply Monte Carlo simulation to evaluate the performance of these five interval estimators. We note that the conditional score test-based interval estimator with a monotonic transformation and the interval estimator based on the Mantel–Haenszel (MH) type point estimator with the logarithmic transformation are generally preferable to the others considered here. We also note that the conditional exact confidence interval can be of use when the total number of matched pairs with discordant responses is small.     

Mean shift and influence measures in linear measurement error models with stochastic linear restrictions

We present influence diagnostics for linear measurement error models with stochastic linear restrictions using the corrected likelihood of Nakamura in 1990. The case deletion and mean shift outlier models are developed to identify outlying and influential observations. We derive a corrected score test statistic for outlier detection based on mean shift outlier models. The analogs of Cook's distance and likelihood distance are proposed to determine influential observations based on case deletion models. A parametric bootstrap procedure is used to obtain empirical distributions of the test statistics and a simulation study has been used to evaluate the performance of the proposed estimators based on the mean squares error criterion and the score test statistic. Finally, a numerical example is given to illustrate the theoretical results.     

Use of log−log survival function in modeling time-covariate interactions in Cox regression

Plotting of log−log survival functions against time for different categories or combinations of categories of covariates is perhaps the easiest and most commonly used graphical tool for checking proportional hazards (PH) assumption. One problem in the utilization of the technique is that the covariates need to be categorical or made categorical through appropriate grouping of the continuous covariates. Subjectivity in the decision making on the basis of eye-judgment of the plots and frequent inconclusiveness arising in situations where the number of categories and/or covariates gets larger are among other limitations of this technique. This paper proposes a non-graphical (numerical) test of the PH assumption that makes use of log−log survival function. The test enables checking proportionality for categorical as well as continuous covariates and overcomes the other limitations of the graphical method. Observed power and size of the test are compared to some other tests of its kind through simulation experiments. Simulations demonstrate that the proposed test is more powerful than some of the most sensitive tests in the literature in a wide range of survival situations. An example of the test is given using the widely used gastric cancer data.     

Score test for homogeneity of dispersion in generalized Poisson mixed models with excess zeros

In many applications, the clustered count data often contain excess zeros and the zero-inflated generalized Poisson mixed (ZIGPM) regression model may be suitable. However, dispersion in ZIGPM is often treated as fixed unknown parameter, and this assumption may be not appropriate in some situations. In this article, a score test for homogeneity of dispersion parameter in ZIGPM regression model is developed and corresponding test statistic is obtained. Sampling distribution and power of the score test statistic are investigated through Monte Carlo simulation. Finally, results from a biological example illustrate the usefulness of the diagnostic statistic.     

Data-driven tests of uniformity on product manifolds

Data-driven versions of Sobolev tests of uniformity on compact Riemannian manifolds are reviewed and their large-sample asymptotic properties are given. A variant which is suitable for product manifolds is introduced. Data-driven goodness-of-fit tests of multivariate distributions are derived from data-driven tests of uniformity on tori.     

Hypothesis Testing of Hazard Ratio Parameters in Marginal Models for Multivariate Failure Time Data

Marginal hazard models for multivariate failure time data have been studied extensively in recent literature. However, standard hypothesis test statistics based on the likelihood method are not exactly appropriate for this kind of model. In this paper, extensions of the three commonly used likelihood hypothesis test statistics are discussed. Generalized Wald, generalized score and generalized likelihood ratio tests for hazard ratio parameters in a marginal hazard model for multivariate failure time data are proposed and their asymptotic distributions examined. The finite sample properties of these statistics are studied through simulations. The proposed method is applied to data from Busselton Population Health Surveys.     

ON SOME OPTIMALITY PROPERTIES OF FISHER-RAO SCORE FUNCTION IN TESTING AND ESTIMATION

The score function is associated with some optimality features in statistical inference. This review article looks on the central role of the score in testing and estimation. The maximization of the power in testing and the quest for efficiency in estimation lead to score as a guiding principle. In hypothesis testing, the locally most powerful test statistic is the score test or a transformation of it. In estimation, the optimal estimating function is the score. The same link can be made in the case of nuisance parameters: the optimal test function should have maximum correlation with the score of the parameter of primary interest. We complement this result by showing that the same criterion should be satisfied in the estimation problem as well.     

Dynamic Copula-Based Markov Time Series

This article examines a test procedure for checking the constancy of serial dependence via copulas for Markov time series data. It also provides a copula-based modeling approach for the dynamic serial dependence. Various parametric families of copulas offering different dependent structures are investigated. A score test is proposed for checking the constancy of a copula parameter. The score test is constructed and its asymptotic null distribution established under a two-stage estimation procedure. The test does not require specification of the probability distribution for the copula parameter. To capture the dynamics of dependence structure over time, autoregressive moving average and exponential type models are proposed. Illustrations are given based on simulated data and historic coffee prices data.