Adherence to three different strategies to prevent early onset GBS infection in newborns

ProblemDespite the introduction of preventive guidelines, no decrease in the incidence of early onset infection was observed.BackgroundEarly onset group B streptococcal (EOGBS) infection is an important cause of neonatal morbidity and mortality.AimOur study was conducted to determine adherence to three guideline-based group B streptococcus (GBS) preventive strategies.MethodsA prospective experimental study clustered by obstetric collaboration region was performed between March 2013 and August 2014 among midwives, obstetricians and paediatricians in the Netherlands. At baseline, the three regions operated according to the Dutch preventive strategy (founded on the risk-based strategy) in order to prevent EOGBS infection, whereas in the study period they followed either the risk-based, the combination or the Dutch strategy. Adherence was measured prospectively per pregnant woman, using predefined core elements of each preventive strategy: identification of risk factors, maternal GBS screening, application of intrapartum antibiotic prophylaxis and observation of the child. Data about adherence to the core elements were collected from medical records, maternal questionnaires and laboratory test results.FindingsIn the three regions, a total of 121 care providers and 1562 women participated.We found an overall adherence of 90% to the risk-based strategy, 57% to the combination strategy and 89% to the Dutch strategy. Adherence to a strategy in case women had EOGBS risk factors was below 20% in all strategies.DiscussionThe majority of women with EOGBS risk factors did not receive the care prescribed by any of three preventive strategies and were not treated optimally.ConclusionThe risk-based and the Dutch strategy are the recommended strategies for implementation.     

上证30指数股市盈率实证分析

通过对2000年上证30指数股市盈率水平及其影响因素进行实证分析,可以发现,其中股息支付率、每股收益增长率、行业平均市盈率对股票P/E值起主要的解释作用,而股本规模因素,解释力却有限,除每股收益增长率外,各变量的相关性与理论分析基本一致.     

B2C电子商务败因:创新范式研究

B2C电子商务的发展经历了泡沫-失败-复苏的周期,深刻分析其失败的原因,对于今后B2C的发展是有指导意义的。B2C商务模式是一种创新行为,B2C的失败是一种创新行为的失败。本文采用创新理论框架对其失败的原因进行分析。     

Lower bounds on expectations of positive L-statistics from without-replacement models

We consider samples drawn without replacement from finite populations. We establish optimal lower non-negative and upper non-positive bounds on the expectations of linear combinations of order statistics centered about the population mean in units generated by the population central absolute moments of various orders. We also specify the general results for important examples of sample extremes, Gini mean differences and sample range. The paper completes the results of Papadatos and Rychlik [2004. Bounds on expectations of L-statistics from without replacement samples. J. Statist. Plann. Inference 124, 317–336], where sharp negative lower and positive upper bounds on the expectations of the combinations were presented for the without-replacement samples.     

用于1553总线控制器的存储管理单元设计

从消息队列的数据存储结构定义、存储空间规划和控制过程设计三方面讨论了MIL-STD-1553/1773总线控制器的设计实现。在总线控制器的模块化设计方案中,这三个方面构成了总线控制器的核心模块棗存储管理单元,应用该方案可实现具有多消息自动处理功能的总线控制器。     

Test for homogeneity in Hardy–Weinberg normal mixture model

The phenotype of a quantitative trait locus (QTL) is often modeled by a finite mixture of normal distributions. If the QTL effect depends on the number of copies of a specific allele one carries, then the mixture model has three components. In this case, the mixing proportions have a binomial structure according to the Hardy–Weinberg equilibrium. In the search for QTL, a significance test of homogeneity against the Hardy–Weinberg normal mixture model alternative is an important first step. The LOD score method, a likelihood ratio test used in genetics, is a favored choice. However, there is not yet a general theory for the limiting distribution of the likelihood ratio statistic in the presence of unknown variance. This paper derives the limiting distribution of the likelihood ratio statistic, which can be described by the supremum of a quadratic form of a Gaussian process. Further, the result implies that the distribution of the modified likelihood ratio statistic is well approximated by a chi-squared distribution. Simulation results show that the approximation has satisfactory precision for the cases considered. We also give a real-data example.     

叶芝诗歌创作中的东方神秘主义

叶芝诗歌以东方神秘主义的象征著称于世。玫瑰、狮身人面怪、天鹅和螺旋是叶芝诗歌中具有凸现主题意义的意象。其来源有二 ,对《旧约圣经》抒情诗风格的继承是叶芝诗歌抒情性的直接来源 ,东方神秘主义思想指导下的对中国和日本诗歌的模仿学习是叶芝诗歌抒情性的间接来源     

分光光度法测定罗丹明B的实验设计

设计了一个分光光度法教学实验“分光光度法测定罗丹明B”,采用电脑处理实验数据,对所设计的实验的可行性及教学效果进行了探讨.     

60Co-r射线辐射保持系嘉浙B的M2代突变类型分析

用60 CO-r射线直接辐射保持系嘉浙B诱发突变 ,M2 代出现多种变异 ,按变异频率大小从高到底依次为 :叶色突变>早熟突变 >颖尖不退花突变 >高外露率突变 >薄颖壳突变 >花时早 >突变紫稃尖突变 >迟熟突变 ,上述 8个选择项的总突变频率达到 2 .4 19% ,说明辐射诱变改良保持系性状十分有效     

On the asymptotic normality of the L1- and L2-errors in histogram density estimation

The L₁ and L₂-errors of the histogram estimate of a density f from a sample X₁,X₂,…,Xn using a cubic partition are shown to be asymptotically normal without any unnecessary conditions imposed on the density f. The asymptotic variances are shown to depend on f only through the corresponding norm of f. From this follows the asymptotic null distribution of a goodness-of-fit test based on the total variation distance, introduced by Györfi and van der Meulen (1991). This note uses the idea of partial inversion for obtaining characteristic functions of conditional distributions, which goes back at least to Bartlett (1938).