Measuring agreement between two statistics with applications to age standardization

Summary.  We detail a general method for measuring agreement between two statistics. An application is two ratios of directly standardized rates which differ only by the choice of the standard. If the statistics have a high value for the coefficient of agreement then the expected squared difference between the statistics is small relative to the variance of the average of the two statistics, and inferences vary little by changing statistics. The estimation of a coefficient of agreement between two statistics is not straightforward because there is only one pair of observed values, each statistic calculated from the data. We introduce estimators of the coefficient of agreement for two statistics and discuss their use, especially as applied to functions of standardized rates.     

Multivariate outlier detection in incomplete survey data: the epidemic algorithm and transformed rank correlations

Summary.  As a part of the EUREDIT project new methods to detect multivariate outliers in incomplete survey data have been developed. These methods are the first to work with sampling weights and to be able to cope with missing values. Two of these methods are presented here. The epidemic algorithm simulates the propagation of a disease through a population and uses extreme infection times to find outlying observations. Transformed rank correlations are robust estimates of the centre and the scatter of the data. They use a geometric transformation that is based on the rank correlation matrix. The estimates are used to define a Mahalanobis distance that reveals outliers. The two methods are applied to a small data set and to one of the evaluation data sets of the EUREDIT project.     

A modified random-effect procedure for combining risk difference in sets of 2×2 tables from clinical trials

Summary Meta-analyses of sets of clinical trials often combine risk differences from several 2×2 tables according to a random-effects model. The DerSimonian-Laird random-effects procedure, widely used for estimating the populaton mean risk difference, weights the risk difference from each primary study inversely proportional to an estimate of its variance (the sum of the between-study variance and the conditional within-study variance). Because those weights are not independent of the risk differences, however, the procedure sometimes exhibits bias and unnatural behavior. The present paper proposes a modified weighting scheme that uses the unconditional within-study variance to avoid this source of bias. The modified procedure has variance closer to that available from weighting by ideal weights when such weights are known. We studied the modified procedure in extensive simulation experiments using situations whose parameters resemble those of actual studies in medical research. For comparison we also included two unbiased procedures, the unweighted mean and a sample-size-weighted mean; their relative variability depends on the extent of heterogeneity among the primary studies. An example illustrates the application of the procedures to actual data and the differences among the results. This research was supported by Grant HS 05936 from the Agency for Health Care Policy and Research to Harvard University.     

Generalized additive models for location, scale and shape

Summary.  A general class of statistical models for a univariate response variable is presented which we call the generalized additive model for location, scale and shape (GAMLSS). The model assumes independent observations of the response variable y given the parameters, the explanatory variables and the values of the random effects. The distribution for the response variable in the GAMLSS can be selected from a very general family of distributions including highly skew or kurtotic continuous and discrete distributions. The systematic part of the model is expanded to allow modelling not only of the mean (or location) but also of the other parameters of the distribution of y , as parametric and/or additive nonparametric (smooth) functions of explanatory variables and/or random-effects terms. Maximum (penalized) likelihood estimation is used to fit the (non)parametric models. A Newton–Raphson or Fisher scoring algorithm is used to maximize the (penalized) likelihood. The additive terms in the model are fitted by using a backfitting algorithm. Censored data are easily incorporated into the framework. Five data sets from different fields of application are analysed to emphasize the generality of the GAMLSS class of models.     

Flow shop scheduling with deteriorating jobs under dominating machines

This paper addresses no-wait or no-idle flow shop scheduling problems with deteriorating jobs, i.e., jobs whose processing times are an increasing function of their starting time. A simple linear deterioration function is assumed and some dominating relationships between machines can be satisfied. It is shown that for the problems to minimize makespan or weighted sum of completion time, polynomial algorithms still exist, although these problems are more complicated than the classical ones. When the objective is to minimize maximum lateness or maximum tardiness, the solutions of a classical version may not hold.     

Sublinear time width-bounded separators and their application to the protein side-chain packing problem

Given d>2 and a set of n grid points Q in ℜ ^d , we design a randomized algorithm that finds a w-wide separator, which is determined by a hyper-plane, in sublinear time such that Q has at most points on either side of the hyper-plane, and at most points within distance to the hyper-plane, where c _d is a constant for fixed d. In particular, c ₃=1.209. To our best knowledge, this is the first sublinear time algorithm for finding geometric separators. Our 3D separator is applied to derive an algorithm for the protein side-chain packing problem, which improves and simplifies the previous algorithm of Xu (Research in computational molecular biology, 9th annual international conference, pp. 408–422, 2005). This research is supported by Louisiana Board of Regents fund under contract number LEQSF(2004-07)-RD-A-35. The part of this research was done while Bin Fu was associated with the Department of Computer Science, University of New Orleans, LA 70148, USA and the Research Institute for Children, 200 Henry Clay Avenue, New Orleans, LA 70118, USA.     

Decision Making in `Random in a Broad Sense' Environments

It is shown that the uncertainty connected with a `random in a broad sense' (not necessarily stochastic) event always has some `statistical regularity' (SR) in the form of a family of finite-additive probability distributions. The specific principle of guaranteed result in decision making is introduced. It is shown that observing this principle of guaranteed result leads to determine the one optimality criterion corresponding to a decision system with a given `statistical regularity'.     

Interactive Effects of Major Response Facilitators

Practitioners and researchers have long been interested in achieving the highest response rate within resource constraints on their mailed surveys. Achieving this high response rate typically has required the selection of the right mix of response-facilitating techniques. The selection decisions were generally made under the assumption that the response-facilitating techniques act independently of one another. The authors have examined the validity of this independence assumption by identifying the major response facilitators in use and then analyzing the results of 531 independent mail survey studies. The authors conclude that major facilitators do not function independently. In fact, it was found that significant joint action interactive effects on response rates do exist. Practitioners and researchers who are faced with the survey design decisions of choosing response facilitators can receive assistance by reviewing the results of this diverse collection of reported experiences.     

On Sampling Error in Market Share Estimates*

The relative error in the usual estimator of a brand's market share is reformulated in terms of marketing parameters. Such error is shown to be influenced in an important way by market penetration, as well as by variation in brand and product category volume. Of particular interest is the result that the relative error does not depend on the actual share level. Using data from a marketing research firm that supplies share estimates to the health products industry, we find that the relative error may be substantial even when a large sample is available. An upper bound on this relative error is obtained using marketing parameters that can frequently be measured using industry data and a company's internal records, thus reducing the level of judgmental input required in the planning of sample surveys.