Estimation of location extremes within general families of scale mixtures

In this paper, we study the estimation of the minimum and maximum location parameters, respectively, representing the minimum guaranteed lifetime of series and parallel systems of components, within a general class of scale mixtures. The conditional or underlying distribution has only the primary restriction of being a location-scale family with positive support. The mixing distribution is also quite general in that we only assume that it has positive support and finite second moment. For demonstrative purposes several special cases are highlighted such as the gamma, inverse-Gaussian, and discrete mixture. Various estimators, including bootstrap bias corrected estimators, are compared with respect to both mean-squared-error and Pitman's measure of closeness.     

Low dose risk estimation via simultaneous statistical inferences

Summary.  The paper develops and studies simultaneous confidence bounds that are useful for making low dose inferences in quantitative risk analysis. Application is intended for risk assessment studies where human, animal or ecological data are used to set safe low dose levels of a toxic agent, but where study information is limited to high dose levels of the agent. Methods are derived for estimating simultaneous, one-sided, upper confidence limits on risk for end points measured on a continuous scale. From the simultaneous confidence bounds, lower confidence limits on the dose that is associated with a particular risk (often referred to as a bench-mark dose ) are calculated. An important feature of the simultaneous construction is that any inferences that are based on inverting the simultaneous confidence bounds apply automatically to inverse bounds on the bench-mark dose.     

A modified false discovery rate multiple-comparisons procedure for discrete data, applied to human immunodeficiency virus genetics

Summary.  To help to design vaccines for acquired immune deficiency syndrome that protect broadly against many genetic variants of the human immunodeficiency virus, the mutation rates at 118 positions in HIV amino-acid sequences of subtype C versus those of subtype B were compared. The false discovery rate (FDR) multiple-comparisons procedure can be used to determine statistical significance. When the test statistics have discrete distributions, the FDR procedure can be made more powerful by a simple modification. The paper develops a modified FDR procedure for discrete data and applies it to the human immunodeficiency virus data. The new procedure detects 15 positions with significantly different mutation rates compared with 11 that are detected by the original FDR method. Simulations delineate conditions under which the modified FDR procedure confers large gains in power over the original technique. In general FDR adjustment methods can be improved for discrete data by incorporating the modification proposed.     

Simultaneous Confidence Intervals for the Population Cell Means,for Two-by-Two Factorial Data,that Utilize Uncertain Prior Information

Consider a two-by-two factorial experiment with more than one replicate. Suppose that we have uncertain prior information that the two-factor interaction is zero. We describe new simultaneous frequentist confidence intervals for the four population cell means, with simultaneous confidence coefficient 1 ? α, that utilize this prior information in the following sense. These simultaneous confidence intervals define a cube with expected volume that (a) is relatively small when the two-factor interaction is zero and (b) has maximum value that is not too large. Also, these intervals coincide with the standard simultaneous confidence intervals obtained by Tukey’s method, with simultaneous confidence coefficient 1 ? α, when the data strongly contradict the prior information that the two-factor interaction is zero. We illustrate the application of these new simultaneous confidence intervals to a real data set.     

On Pitman's measure of closeness of k-records

Pitman closeness of both the upper and lower k-record statistics to the population quantiles of a location–scale family of distributions is studied. For the population median, the Pitman-closest k-record is also determined. In the case of symmetric distributions, the Pitman closeness probabilities of k-record statistics are shown to be distribution-free, and explicit expressions are also derived for these probabilities. Exact expressions are derived for the required probabilities for uniform and exponential distributions. Numerical results are given for these families and also the Pitman-closest k-record is determined.     

On the Nearness of Records to Population Quantiles with Respect to Order Statistics in the Sense of Pitman Closeness

In this paper, Pitman closeness criterion is used to compare the nearness of record values and order statistics from two independent samples to a specific population quantile of the parent distribution while the underlying distributions are the same. General expressions for the associated Pitman closeness probability are obtained when the support of the parent distribution is bounded and also unbounded. Some distribution-free results are achieved for symmetric distributions. The exponential and uniform distributions are considered for illustrative proposes and exact expressions are obtained in each case.     

Pitman closeness,monotonicity and consistency of best linear unbiased and invariant estimators for exponential distribution under Type II censoring

Comparisons of best linear unbiased estimators with some other prominent estimators have been carried out over the last 50 years since the ground breaking work of Lloyd [E.H. Lloyd, Least squares estimation of location and scale parameters using order statistics, Biometrika 39 (1952), pp. 88–95]. These comparisons have been made under many different criteria across different parametric families of distributions. A noteworthy one is by Nagaraja [H.N. Nagaraja, Comparison of estimators and predictors from two-parameter exponential distribution, Sankhyā Ser. B 48 (1986), pp. 10–18], who made a comparison of best linear unbiased (BLUE) and best linear invariant (BLIE) estimators in the case of exponential distribution. In this paper, continuing along the same lines by assuming a Type II right censored sample from a scaled-exponential distribution, we first compare BLUE and BLIE of the exponential mean parameter in terms of Pitman closeness (nearness) criterion. We show that the BLUE is always Pitman closer than the BLIE. Next, we introduce the notions of Pitman monotonicity and Pitman consistency, and then establish that both BLUE and BLIE possess these two properties.     

The numerical evaluation of the distribution function of a bilinear from to a quadratic from with econometric examples

This paper considers a general and computationally convenient method of evaluating the distribution function of statistics that are the ratio of a bilinear form to a quadratic form. Numerous Economemc applications of the method are given.     

Estimation of Nonparametric Models With Simultaneity

We introduce methods for estimating nonparametric, nonadditive models with simultaneity. The methods are developed by directly connecting the elements of the structural system to be estimated with features of the density of the observable variables, such as ratios of derivatives or averages of products of derivatives of this density. The estimators are therefore easily computed functionals of a nonparametric estimator of the density of the observable variables. We consider in detail a model where to each structural equation there corresponds an exclusive regressor and a model with one equation of interest and one instrument that is included in a second equation. For both models, we provide new characterizations of observational equivalence on a set, in terms of the density of the observable variables and derivatives of the structural functions. Based on those characterizations, we develop two estimation methods. In the first method, the estimators of the structural derivatives are calculated by a simple matrix inversion and matrix multiplication, analogous to a standard least squares estimator, but with the elements of the matrices being averages of products of derivatives of nonparametric density estimators. In the second method, the estimators of the structural derivatives are calculated in two steps. In a first step, values of the instrument are found at which the density of the observable variables satisfies some properties. In the second step, the estimators are calculated directly from the values of derivatives of the density of the observable variables evaluated at the found values of the instrument. We show that both pointwise estimators are consistent and asymptotically normal.     

Comparison of preliminary test estimators based on generalized order statistics from proportional hazard family using Pitman measure of closeness

In this article, based on generalized order statistics from a family of proportional hazard rate model, we use a statistical test to generate a class of preliminary test estimators and shrinkage preliminary test estimators for the proportionality parameter. These estimators are compared under Pitman measure of closeness (PMC) as well as MSE criteria. Although the PMC suffers from non transitivity, in the first class of estimators, it has the transitivity property and we obtain the Pitman-closest estimator. Analytical and graphical methods are used to show the range of parameter in which preliminary test and shrinkage preliminary test estimators perform better than their competitor estimators. Results reveal that when the prior information is not too far from its real value, the proposed estimators are superior based on both mentioned criteria.