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1.
Stephen J. Ruberg Frank E. Harrell Jr. Margaret Gamalo-Siebers Lisa LaVange J. Jack Lee Karen Price 《The American statistician》2019,73(1):319-327
ABSTRACTThe cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making. 相似文献
2.
David R. Bickel 《统计学通讯:理论与方法》2020,49(11):2703-2712
AbstractConfidence sets, p values, maximum likelihood estimates, and other results of non-Bayesian statistical methods may be adjusted to favor sampling distributions that are simple compared to others in the parametric family. The adjustments are derived from a prior likelihood function previously used to adjust posterior distributions. 相似文献
3.
廖晶 《中南大学学报(社会科学版)》2005,11(3):410-412
声音、节奏等具有伴随意义,有时是对语言本身意义的补充.在翻译时力求音义对应是实现等效翻译的一种重要手段.当然,英汉语音在结构、功能和表达方式上的差异也使音义对应有一定的限度. 相似文献
4.
Bram Thuysbaert 《Journal of Economic Inequality》2008,6(1):33-55
Empirical applications of poverty measurement often have to deal with a stochastic weighting variable such as household size.
Within the framework of a bivariate distribution function defined over income and weight, I derive the limiting distributions
of the decomposable poverty measures and of the ordinates of stochastic dominance curves. The poverty line is allowed to depend
on the income distribution. It is shown how the results can be used to test hypotheses concerning changes in poverty. The
inference procedures are briefly illustrated using Belgian data.
An erratum to this article can be found at 相似文献
5.
6.
Gary Pollock 《Journal of the Royal Statistical Society. Series A, (Statistics in Society)》2007,170(1):167-183
Summary. Social science applications of sequence analysis have thus far involved the development of a typology on the basis of an analysis of one or two variables which have had a relatively low number of different states. There is a yet unexplored potential for sequence analysis to be applied to a greater number of variables and thereby a much larger state space. The development of a typology of employment experiences, for example, without reference to data on changes in housing, marital and family status is arguably inadequate. The paper demonstrates the use of sequence analysis in the examination of multivariable combinations of status as they change over time and shows that this method can provide insights that are difficult to achieve through other analytic methods. The data that are examined here provide support to intuitive understandings of clusters of common experiences which are both life course specific and related to socio-economic factors. Housing tenure is found to be of key importance in understanding the holistic trajectories that are examined. This suggests that life course trajectories are sharply differentiated by experience of social housing. 相似文献
7.
Owing to the extreme quantiles involved, standard control charts are very sensitive to the effects of parameter estimation and non-normality. More general parametric charts have been devised to deal with the latter complication and corrections have been derived to compensate for the estimation step, both under normal and parametric models. The resulting procedures offer a satisfactory solution over a broad range of underlying distributions. However, situations do occur where even such a large model is inadequate and nothing remains but to consider non- parametric charts. In principle, these form ideal solutions, but the problem is that huge sample sizes are required for the estimation step. Otherwise the resulting stochastic error is so large that the chart is very unstable, a disadvantage that seems to outweigh the advantage of avoiding the model error from the parametric case. Here we analyse under what conditions non-parametric charts actually become feasible alternatives for their parametric counterparts. In particular, corrected versions are suggested for which a possible change point is reached at sample sizes that are markedly less huge (but still larger than the customary range). These corrections serve to control the behaviour during in-control (markedly wrong outcomes of the estimates only occur sufficiently rarely). The price for this protection will clearly be some loss of detection power during out-of-control. A change point comes in view as soon as this loss can be made sufficiently small. 相似文献
8.
对企业本质的认识是微观经济学中的一个重要问题,其对中国的国企改革有着重要意义。本文中,我们对企业的合约本质进行了经济理论探索和统计检验,并突出关注企业的激励合约问题。 相似文献
9.
统计调查课程的现状与调整思路 总被引:1,自引:0,他引:1
文章从统计调查课程设置的现状出发,介绍了当前随着社会经济的发展和统计调查方法体系的改革,统计调查理论体系以及统计调查课程设置的不足,叙述了统计调查课程调整的思路。要实施这个思路,必须重视统计调查对象内容的变化,并注重借鉴国外成熟的经验。为适应形势的发展,随着现行统计调查方法体系的调整与完善,对统计调查课程也要作相应的调整。 相似文献
10.
Paramjit S. Gill Tim B. Swartz 《Journal of the Royal Statistical Society. Series C, Applied statistics》2004,53(2):249-260
Summary. A fully Bayesian analysis of directed graphs, with particular emphasis on applica- tions in social networks, is explored. The model is capable of incorporating the effects of covariates, within and between block ties and multiple responses. Inference is straightforward by using software that is based on Markov chain Monte Carlo methods. Examples are provided which highlight the variety of data sets that can be entertained and the ease with which they can be analysed. 相似文献