Testing hypotheses for the growth curve model when the data are incomplete

Kleinbaum (1973) developed a generalized growth curve model for analyzing incomplete longitudinal data. In this paper the small sample properties of several related test statistics are investigated via Monte Carlo techniques. The covariance matrix is estimated by each of three non-iterative methods. The null and non-null distributions of these test statistics are examined.     

A bootstrap control chart for inverse Gaussian percentiles

The conventional Shewhart-type control chart is developed essentially on the central limit theorem. Thus, the Shewhart-type control chart performs particularly well when the observed process data come from a near-normal distribution. On the other hand, when the underlying distribution is unknown or non-normal, the sampling distribution of a parameter estimator may not be available theoretically. In this case, the Shewhart-type charts are not available. Thus, in this paper, we propose a parametric bootstrap control chart for monitoring percentiles when process measurements have an inverse Gaussian distribution. Through extensive Monte Carlo simulations, we investigate the behaviour and performance of the proposed bootstrap percentile charts. The average run lengths of the proposed percentage charts are investigated.     

A comparative study of confidence intervals for negative binomial proportion

In this paper, we investigate four existing and three new confidence interval estimators for the negative binomial proportion (i.e., proportion under inverse/negative binomial sampling). An extensive and systematic comparative study among these confidence interval estimators through Monte Carlo simulations is presented. The performance of these confidence intervals are evaluated in terms of their coverage probabilities and expected interval widths. Our simulation studies suggest that the confidence interval estimator based on saddlepoint approximation is more appealing for large coverage levels (e.g., nominal level≤1% ) whereas the score confidence interval estimator is more desirable for those commonly used coverage levels (e.g., nominal level>1% ). We illustrate these confidence interval construction methods with a real data set from a maternal congenital heart disease study.     

A permutation alternative and other test procedures for spatially correlated data in one-way anova

Research in many disciplines involves data with spatially correlated observations. Spatial dependence violates the independent errors assumption required for techniques such as the standard one-way analysis of variance for a completely randomized design. The testing methodology within the correlated errors approach has not been investigated within a spatial context. For one-way fixed effects analysis of variance, a permutation test and tests associated with the correlated errors approach are investigated through simulation. No single test was superior with respect to both power and size but the standard Wald F test and a simple adjustment to it performed well overall.     

Effect of a new selection procedure on adaptive estimation

Adaptive estimation of parameters of some failure time distributionsis considered. A new procedure named the F-procedure has beendeveloped for selecting an appropriate model out of two possible models by Pandey et.al. (1991). Applying this F-procedure adaptive estimatorsof parameters of exponential, Wei bull, inverse Gaussian (IG) and Wald failure time distributions have been proposed in this paper. Comparison of these estimators has been undertaken with MLE's of the respective parameters and with some previous adaptiveestimators by simulation of samples using the Monte Carlo method.Adaptive estimation of parameters of some failure time distributions is considered. A new procedure named the F-procedure has been developedfor selecting an appropriate model out of two possible models by Pandey et.al. (1991). Applying this F-procedure adaptive estimators of parameters of exponential, Wei bull, inverse Gaussian (IG) and Wald failure time distributions have been proposed in this paper. Comparison of these estimators has been undertaken with MLE's of the respective parameters and with some previous adaptive estimators by simulation of samples using the Monte Carlo method.     

Asymptotic relative efficiency of wald tests in measurement error models

In this paper, asymptotic relative efficiency (ARE) of Wald tests for the Tweedie class of models with log-linear mean, is considered when the aux¬iliary variable is measured with error. Wald test statistics based on the naive maximum likelihood estimator and on a consistent estimator which is obtained by using Nakarnura's (1990) corrected score function approach are defined. As shown analytically, the Wald statistics based on the naive and corrected score function estimators are asymptotically equivalents in terms of ARE. On the other hand, the asymptotic relative efficiency of the naive and corrected Wald statistic with respect to the Wald statistic based on the true covariate equals to the square of the correlation between the unobserved and the observed co-variate. A small scale numerical Monte Carlo study and an example illustrate the small sample size situation.     

A comparative study of confidence intervals to assess biosimilarity from analytical data

Assessment of analytical similarity of tier 1 quality attributes is based on a set of hypotheses that tests the mean difference of reference and test products against a margin adjusted for standard deviation of the reference product. Thus, proper assessment of the biosimilarity hypothesis requires statistical tests that account for the uncertainty associated with the estimations of the mean differences and the standard deviation of the reference product. Recently, a linear reformulation of the biosimilarity hypothesis has been proposed, which facilitates development and implementation of statistical tests. These statistical tests account for the uncertainty in the estimation process of all the unknown parameters. In this paper, we survey methods for constructing confidence intervals for testing the linearized reformulation of the biosimilarity hypothesis and also compare the performance of the methods. We discuss test procedures using confidence intervals to make possible comparison among recently developed methods as well as other previously developed methods that have not been applied for demonstrating analytical similarity. A computer simulation study was conducted to compare the performance of the methods based on the ability to maintain the test size and power, as well as computational complexity. We demonstrate the methods using two example applications. At the end, we make recommendations concerning the use of the methods.     

Asymptotic inference in poverty indices: an empirical processes approach

We derive an empirical poverty index containing most of those proposed in the literature. Then, we study its asymptotic behavior by using empirical processes theory. From the results obtained, we derive a Wald-type test for comparing a vector of theoretical poverty indices to a vector of reference indices. We study the test statistic under the null hypothesis of equality, fixed alternatives, and a sequence of local alternatives. A simulation experiment conducted shows that our test performs well for exponential and Pareto data.     

COMPARATIVE CALIBRATION WITH SUBGROUPS

The main object of this paper is to consider structural comparative calibration models under the assumption that the unknown quantity being measured is not identically distributed for all units. We consider the situation where the mean of the unknown quantity being measured is different within subgroups of the population. Method of moments and maximum likelihood estimators are considered for estimating the parameters in the model. Large sample inference is facilitated by the derivation of the asymptotic variances. An application to a data set which indeed motivated the consideration of such general model and was obtained by measuring the heights of a group of trees with five different instruments is considered.     

Hypothesis Testing of Hazard Ratio Parameters in Marginal Models for Multivariate Failure Time Data

Marginal hazard models for multivariate failure time data have been studied extensively in recent literature. However, standard hypothesis test statistics based on the likelihood method are not exactly appropriate for this kind of model. In this paper, extensions of the three commonly used likelihood hypothesis test statistics are discussed. Generalized Wald, generalized score and generalized likelihood ratio tests for hazard ratio parameters in a marginal hazard model for multivariate failure time data are proposed and their asymptotic distributions examined. The finite sample properties of these statistics are studied through simulations. The proposed method is applied to data from Busselton Population Health Surveys.