A modified random-effect procedure for combining risk difference in sets of 2×2 tables from clinical trials

Summary Meta-analyses of sets of clinical trials often combine risk differences from several 2×2 tables according to a random-effects model. The DerSimonian-Laird random-effects procedure, widely used for estimating the populaton mean risk difference, weights the risk difference from each primary study inversely proportional to an estimate of its variance (the sum of the between-study variance and the conditional within-study variance). Because those weights are not independent of the risk differences, however, the procedure sometimes exhibits bias and unnatural behavior. The present paper proposes a modified weighting scheme that uses the unconditional within-study variance to avoid this source of bias. The modified procedure has variance closer to that available from weighting by ideal weights when such weights are known. We studied the modified procedure in extensive simulation experiments using situations whose parameters resemble those of actual studies in medical research. For comparison we also included two unbiased procedures, the unweighted mean and a sample-size-weighted mean; their relative variability depends on the extent of heterogeneity among the primary studies. An example illustrates the application of the procedures to actual data and the differences among the results. This research was supported by Grant HS 05936 from the Agency for Health Care Policy and Research to Harvard University.     

A partial score test for difference among heterogeneous populations

In event time data analysis, comparisons between distributions are made by the logrank test. When the data appear to contain crossing hazards phenomena, nonparametric weighted logrank statistics are usually suggested to accommodate different-weighted functions to increase the power. However, the gain in power by imposing different weights has its limits since differences before and after the crossing point may balance each other out. In contrast to the weighted logrank tests, we propose a score-type statistic based on the semiparametric-, heteroscedastic-hazards regression model of Hsieh [2001. On heteroscedastic hazards regression models: theory and application. J. Roy. Statist. Soc. Ser. B 63, 63–79.], by which the nonproportionality is explicitly modeled. Our score test is based on estimating functions derived from partial likelihood under the heteroscedastic model considered herein. Simulation results show the benefit of modeling the heteroscedasticity and power of the proposed test to two classes of weighted logrank tests (including Fleming–Harrington's test and Moreau's locally most powerful test), a Renyi-type test, and the Breslow's test for acceleration. We also demonstrate the application of this test by analyzing actual data in clinical trials.     

A new approach to statistical efficiency of weighted least squares fitting algorithms for reparameterization of nonlinear regression models

We study nonlinear least-squares problem that can be transformed to linear problem by change of variables. We derive a general formula for the statistically optimal weights and prove that the resulting linear regression gives an optimal estimate (which satisfies an analogue of the Rao-Cramer lower bound) in the limit of small noise.     

Construction of Fuzzy Control Charts Based on Weighted Possibilistic Mean

The problem of constructing control charts for fuzzy data has been considered in literature. The proposed transformation approaches and direct fuzzy approaches have their advantages and disadvantages. The representative values charts based on transformation methods are often recommended in practical application. For representing a fuzzy set by a crisp value, the weight of importance of the members assigned with some membership levels in a fuzzy set should be considered, and the possibility theory can be employed to deal with such problem. In this article, we propose to employ the weighted possibilistic mean (WPM), weighted interval valued possibilistic mean (WIVPM) of fuzzy number as a sort of representative values for the fuzzy attribute data, and establish new fuzzy control charts with WPM and WIVPM. The performance of the charts is compared to the existing fuzzy charts with a fuzzy c-chart example via newly defined average number of inspection for variation of control state.     

Some Results Based on a Version of the Generalized Dynamic Entropies

We propose new dynamic measures of uncertainty based on the notion of generalized dynamic entropy introduced in Di Crescenzo and Longobardi (2006). These can uniquely determine distribution functions in continuous and discrete cases, and the characterizations of some well-known distributions are provided. We also define some orderings and aging notions based on the generalized dynamic measures, and prove some of their properties, obtaining as corollaries results that have recently appeared in the literature.     

On the existence of maximum likelihood estimates for weighted logistic regression

The problems of existence and uniqueness of maximum likelihood estimates for logistic regression were completely solved by Silvapulle in 1981 and Albert and Anderson in 1984. In this paper, we extend the well-known results by Silvapulle and by Albert and Anderson to weighted logistic regression. We analytically prove the equivalence between the overlap condition used by Albert and Anderson and that used by Silvapulle. We show that the maximum likelihood estimate of weighted logistic regression does not exist if there is a complete separation or a quasicomplete separation of the data points, and exists and is unique if there is an overlap of data points. Our proofs and results for weighted logistic apply to unweighted logistic regression.     

On the accuracy and cost of numerical integration in several variables ∗

Identical numerical integration experiments are performed on a CYBER 205 and an IBM 3081 in order to gauge the relative performance of several methods of integration. The methods employed are the general methods of Gauss-Legendre, iterated Gauss-Legendre, Newton-Cotes, Romberg and Monte Carlo as well as three methods, due to Owen, Dutt, and Clark respectively, for integrating the normal density. The bi- and trivariate normal densities and four other functions are integrated; the latter four have integrals expressible in closed form and some of them can be parameterized to exhibit singularities or highly periodic behavior. The various Gauss-Legendre methods tend to be most accurate (when applied to the normal density they are even more accurate than the special purpose methods designed for the normal) and while they are not the fastest, they are at least competitive. In scalar mode the CYBER is about 2-6 times faster than the IBM 3081 and the speed advantage of vectorised to scalar mode ranges from 6 to 15. Large scale econometric problems of the probit type should now be routinely soluble.     

Uniform Test for Predictive Regression With AR Errors

Testing predictability is of importance in economics and finance. Based on a predictive regression model with independent and identically distributed errors, some uniform tests have been proposed in the literature without distinguishing whether the predicting variable is stationary or nearly integrated. In this article, we extend the empirical likelihood methods of Zhu, Cai, and Peng with independent errors to the case of an AR error process. Again, the proposed new tests do not need to know whether the predicting variable is stationary or nearly integrated, and whether it has a finite variance or an infinite variance. A simulation study shows the new methodologies perform well in finite sample.     

Precise large deviations for the difference of two sums of END random variables with heavy tails

Assume that there are two types of insurance contracts in an insurance company, and the ith related claims are denoted by {X_ij, j ? 1}, i = 1, 2. In this article, the asymptotic behaviors of precise large deviations for non random difference ∑^n₁(t)_{j = 1}X_1j ? ∑^n₂(t)_{j = 1}X_2j and random difference ∑^N₁(t)_{j = 1}X_1j ? ∑^N₂(t)_{j = 1}X_2j are investigated, and under several assumptions, some corresponding asymptotic formulas are obtained.