A modified random-effect procedure for combining risk difference in sets of 2×2 tables from clinical trials

Summary Meta-analyses of sets of clinical trials often combine risk differences from several 2×2 tables according to a random-effects model. The DerSimonian-Laird random-effects procedure, widely used for estimating the populaton mean risk difference, weights the risk difference from each primary study inversely proportional to an estimate of its variance (the sum of the between-study variance and the conditional within-study variance). Because those weights are not independent of the risk differences, however, the procedure sometimes exhibits bias and unnatural behavior. The present paper proposes a modified weighting scheme that uses the unconditional within-study variance to avoid this source of bias. The modified procedure has variance closer to that available from weighting by ideal weights when such weights are known. We studied the modified procedure in extensive simulation experiments using situations whose parameters resemble those of actual studies in medical research. For comparison we also included two unbiased procedures, the unweighted mean and a sample-size-weighted mean; their relative variability depends on the extent of heterogeneity among the primary studies. An example illustrates the application of the procedures to actual data and the differences among the results. This research was supported by Grant HS 05936 from the Agency for Health Care Policy and Research to Harvard University.     

沈阳市产业关联和产业结构变化的实证研究

沈阳在高速经济增长的同时 ,工业化的进程加速 ,产业结构发生很大变化。本文将利用 1 996年和 2 0 0 0年两个时点的投入产出表 ,分析沈阳市产业关联和产业结构变动规律和特征。     

Maximum Likelihood Inference for Log-linear Models Subject to Constraints of Double Monotone Dependence

To model an hypothesis of double monotone dependence between two ordinal categorical variables A and B usually a set of symmetric odds ratios defined on the joint probability function is subject to linear inequality constraints. Conversely in this paper two sets of asymmetric odds ratios defined, respectively, on the conditional distributions of A given B and on the conditional distributions of B given A are subject to linear inequality constraints. If the joint probabilities are parameterized by a saturated log-linear model, these constraints are nonlinear inequality constraints on the log-linear parameters. The problem here considered is a non-standard one both for the presence of nonlinear inequality constraints and for the fact that the number of these constraints is greater than the number of the parameters of the saturated log-linear model.This work has been supported by the COFIN 2002 project, references 2002133957_002, 2002133957_004. Preliminary findings have been presented at SIS (Società Italiana di Statistica) Annual Meeting, Bari, 2004.     

On tests of symmetry,marginal homogeneity and quasi-symmetry in two-way contingency tables based on minimum φ-divergence estimator with constraints

The restricted minimum φ-divergence estimator, [Pardo, J.A., Pardo, L. and Zografos, K., 2002, Minimum φ-divergence estimators with constraints in multinomial populations. Journal of Statistical Planning and Inference, 104, 221–237], is employed to obtain estimates of the cell frequencies of an I×I contingency table under hypotheses of symmetry, marginal homogeneity or quasi-symmetry. The associated φ-divergence statistics are distributed asymptotically as chi-squared distributions under the null hypothesis. The new estimators and test statistics contain, as particular cases, the classical estimators and test statistics previously presented in the literature for the cited problems. A simulation study is presented, for the symmetry problem, to choose the best function φ₂ for estimation and the best function φ₁ for testing.     

The limitations of using school league tables to inform school choice

Summary. In England, so-called 'league tables' based on examination results and test scores are published annually, ostensibly to inform parental choice of secondary schools. A crucial limitation of these tables is that the most recent published information is based on the current performance of a cohort of pupils who entered secondary schools several years earlier, whereas for choosing a school it is the future performance of the current cohort that is of interest. We show that there is substantial uncertainty in predicting such future performance and that incorporating this uncertainty leads to a situation where only a handful of schools' future performances can be separated from both the overall mean and from one another with an acceptable degree of precision. This suggests that school league tables, including value-added tables, have very little to offer as guides to school choice.     

Bayesian Analysis of Contingency Tables

ABSTRACT

The display of the data by means of contingency tables is used in different approaches to statistical inference, for example, to broach the test of homogeneity of independent multinomial distributions. We develop a Bayesian procedure to test simple null hypotheses versus bilateral alternatives in contingency tables. Given independent samples of two binomial distributions and taking a mixed prior distribution, we calculate the posterior probability that the proportion of successes in the first population is the same as in the second. This posterior probability is compared with the p-value of the classical method, obtaining a reconciliation between both results, classical and Bayesian. The obtained results are generalized for r × s tables.     

Marginal homogeneity,symmetry, and independence

A contingency table of the mc form provides a convenient summary of data when c individuals in a matched set9 each belonging to a different one of c classifications, are identified as belonging to one of m categories, A study in which matched sets (c=3) of 1 case, 1 hospital control, and 1 neighborhood control are classified into one of m=4 occupational categories would be an example, Independence in the cxm tables for each of the matched sets implies symmetry in the summary mc table with consequent marginal homogeneity. Adaptation of the Mantel-Haenszel procedure for testing independence to the case of many cxm tables so as to yield a chi square with (cl)(ml) degrees of freedom (DF) provides a test of marginal homogeneity in the summary mc table. This can be viewed as a test of symmetry directed against alternatives which would make for marginal inhomogeneity and can differ     

Social Background Differences in Early Family Behavior

Social background has historically been recognized as a major factor influencing family behavior, though recent work has largely emphasized racial/ethnic influences. Here we use 1994 – 1995 and 2001 – 2002 Add Health data to examine the cohabitation, first marriage, and first birth experience of young women. In a multistate life table context, hypothetical cohorts specified in terms of race and mother’s education are followed, from age 11 to age 24, as they move through 6 family‐related statuses. The results indicate that, for both Black and White women, a higher level of maternal education is generally associated with less cohabitation, less marriage, fewer first births, and a higher percentage of women who experience none of those transitions before age 24. Racial and social background differences are conceptually and empirically distinct. Because mother’s education is associated with substantially different trajectories of early family behavior for both Blacks and Whites, we argue that social background merits increased attention in research on contemporary American family patterns.     

Point-symmetry models and decomposition for collapsed square contingency tables

For square contingency tables with ordered categories, there may be some cases that one wants to analyze them by considering collapsed tables with some adjacent categories combined in the original table. This paper proposes three kinds of new models which have the structure of point-symmetry (PS), quasi point-symmetry and marginal point-symmetry for collapsed square tables. This paper also gives a decomposition of the PS model for collapsed square tables. The father's and his daughter's occupational mobility data are analyzed using new models.     

Information preserving statistical obfuscation

The problem of limiting the disclosure of information gathered on a set of companies or individuals (the respondents) is considered, the aim being to provide useful information while preserving confidentiality of sensitive information. The paper proposes a method which explicitly preserves certain information contained in the data. The data are assumed to consist of two sets of information on each respondent: public data and specific survey data. It is assumed in this paper that both sets of data are liable to be released for a subset of respondents. However, the public data will be altered in some way to preserve confidentiality whereas the specific survey data is to be disclosed without alteration. The paper proposes a model based approach to this problem by utilizing the information contained in the sufficient statistics obtained from fitting a model to the public data by conditioning on the survey data. Deterministic and stochastic variants of the method are considered.