The ‘right time’ – negotiating the timing of interviews with vulnerable young people

Participant retention is a key factor in determining the success of longitudinal research. Challenges in re-locating and retaining participants over the long term are major issues for researchers working with young people who face adversity and experience frequent changes in circumstances. This article reports on a study of vulnerable young people and their transition into adulthood. Rather than the more conventional schedule-based approach to locating and re-interviewing young people, a relational process, the ‘right time’ framework, was used to facilitate young people's involvement in the study. Embedded in the ‘right time’ framework is recognition of the diverse and fluctuating circumstances that shape young people's availability for interviews. Several case examples are considered which amplify the way that the ‘right time’ framework allowed the research to navigate around these circumstances. The case examples highlight the value young people attached to being involved in the research, the influence on the ‘right time’ of wider relational tensions for young people and the need to negotiate researcher status as a different sort of adult. The ‘right time’ framework contributed to a high retention rate in the study generating a more representative sample and enhancing the subsequent data analysis by providing valuable insights into the lives of these vulnerable young people.     

二元对立原则与文学赏析

二元对立现象广泛存在于文学作品之中,二元对立原则也成为一种重要的文学分析方法。运用此原则研究体现二元对立内涵的文学作品,有助于更全面,深入地发掘作品的内涵和艺术精髓。     

Backfitting Random Varying-Coefficient Models with Time-Dependent Smoothing Covariates

Abstract.  In this paper, we propose a random varying-coefficient model for longitudinal data. This model is different from the standard varying-coefficient model in the sense that the time-varying coefficients are assumed to be subject-specific, and can be considered as realizations of stochastic processes. This modelling strategy allows us to employ powerful mixed-effects modelling techniques to efficiently incorporate the within-subject and between-subject variations in the estimators of time-varying coefficients. Thus, the subject-specific feature of longitudinal data is effectively considered in the proposed model. A backfitting algorithm is proposed to estimate the coefficient functions. Simulation studies show that the proposed estimation methods are more efficient in finite-sample performance compared with the standard local least squares method. An application to an AIDS clinical study is presented to illustrate the proposed methodologies.     

Choice of the primary analysis in longitudinal clinical trials

Missing data, and the bias they can cause, are an almost ever‐present concern in clinical trials. The last observation carried forward (LOCF) approach has been frequently utilized to handle missing data in clinical trials, and is often specified in conjunction with analysis of variance (LOCF ANOVA) for the primary analysis. Considerable advances in statistical methodology, and in our ability to implement these methods, have been made in recent years. Likelihood‐based, mixed‐effects model approaches implemented under the missing at random (MAR) framework are now easy to implement, and are commonly used to analyse clinical trial data. Furthermore, such approaches are more robust to the biases from missing data, and provide better control of Type I and Type II errors than LOCF ANOVA. Empirical research and analytic proof have demonstrated that the behaviour of LOCF is uncertain, and in many situations it has not been conservative. Using LOCF as a composite measure of safety, tolerability and efficacy can lead to erroneous conclusions regarding the effectiveness of a drug. This approach also violates the fundamental basis of statistics as it involves testing an outcome that is not a physical parameter of the population, but rather a quantity that can be influenced by investigator behaviour, trial design, etc. Practice should shift away from using LOCF ANOVA as the primary analysis and focus on likelihood‐based, mixed‐effects model approaches developed under the MAR framework, with missing not at random methods used to assess robustness of the primary analysis. Copyright © 2004 John Wiley & Sons, Ltd.     

Marginal and association regression models for longitudinal binary data with drop‐outs: A likelihood‐based approach

Longitudinal data often contain missing observations, and it is in general difficult to justify particular missing data mechanisms, whether random or not, that may be hard to distinguish. The authors describe a likelihood‐based approach to estimating both the mean response and association parameters for longitudinal binary data with drop‐outs. They specify marginal and dependence structures as regression models which link the responses to the covariates. They illustrate their approach using a data set from the Waterloo Smoking Prevention Project They also report the results of simulation studies carried out to assess the performance of their technique under various circumstances.     

Fuzzy K-means clustering models for triangular fuzzy time trajectories

We focus our attention on the classification of fuzzy time trajectories with triangular membership function, described by a given set of individuals. To this purpose, we adopt a fullyinformational approach, explicitly recognizing the informational nature shared by the ingredients of the classification procedure: the observed data (Empirical Information) and the classification model (Theoretical Information). In particular, by supposing that the informational paradigm has a fuzzy nature, we suggest three fuzzy clustering models allowing the classification of the triangular fuzzy time trajectories, based on the analysis of the cross sectional and/or longitudinal characteristics of their components (centers and spreads). Two applicative examples are illustrated.     

Semi-parametric estimation of ROC curves based on binomial regression modelling

This paper presents a method of estimating a receiver operating characteristic (ROC) curve when the underlying diagnostic variable X is continuous and fully observed. The new method is based on modelling the probability of response given X , rather than the distribution of X given response. The method offers advantages in modelling flexibility and computational simplicity. The resulting ROC curve estimates are semi-parametric and can, in principle, take an infinite variety of shapes. Moreover, model selection can be based on standard methods within the binomial regression framework. Statistical accuracy of the curve estimate is provided by a simply implemented bootstrap approach.     

论合同法上的情事变更原则

法律上对情事变更原则的适用规定了严格的条件,适用情事变更原则的法律效力主要体现变更合同、解除合同两个方面,而且情事变更与不可抗力、商业风险存在着明显的差别。社会主义市场经济的发展及与国际市场的接轨,决定了情事变更原则应当成为我国合同法上最重要的法律原则之一,它有利于进一步完善我国现行合同法律制度。     

Race and Population Change: A Longitudinal Look at Cleveland Neighborhoods

This paper investigates the relationship of racial composition to neighborhood population change from 1910 to 1990 in the Cleveland metropolitan area. To better understand the long-term dynamics of urban neighborhood change, we focus our analysis upon the longitudinal relationship of race, socioeconomic status, and life cycle stage to changes in neighborhood population densities. First, we find that the more established neighborhoods of the African-American community have experienced dramatic declines in population since 1950, a pattern that represents a clear change from the earlier part of the twentieth century. Second, population loss is experienced through a variety of mechanisms, including the demolition of dwellings, the increase in housing vacancy, and the decline of household size. Third, much of this population loss should be interpreted within the context of high economic distress, occurring most frequently in older African-American communities. Over time, economic distress appears to be more important than race in and of itself in leading to the loss of neighborhood populations.     

Optimal sampling for repeated binary measurements

The authors consider the optimal design of sampling schedules for binary sequence data. They propose an approach which allows a variety of goals to be reflected in the utility function by including deterministic sampling cost, a term related to prediction, and if relevant, a term related to learning about a treatment effect To this end, they use a nonparametric probability model relying on a minimal number of assumptions. They show how their assumption of partial exchangeability for the binary sequence of data allows the sampling distribution to be written as a mixture of homogeneous Markov chains of order k. The implementation follows the approach of Quintana & Müller (2004), which uses a Dirichlet process prior for the mixture.