An analytic method for randomized trials with informative censoring: Part 1

Consider a randomized trial in which time to the occurrence of a particular disease, say pneumocystis pneumonia in an AIDS trial or breast cancer in a mammographic screening trial, is the failure time of primary interest. Suppose that time to disease is subject to informative censoring by the minimum of time to death, loss to and end of follow-up. In such a trial, the censoring time is observed for all study subjects, including failures. In the presence of informative censoring, it is not possible to consistently estimate the effect of treatment on time to disease without imposing additional non-identifiable assumptions. The goals of this paper are to specify two non-identifiable assumptions that allow one to test for and estimate an effect of treatment on time to disease in the presence of informative censoring. In a companion paper (Robins, 1995), we provide consistent and reasonably efficient semiparametric estimators for the treatment effect under these assumptions. In this paper we largely restrict attention to testing. We propose tests that, like standard weighted-log-rank tests, are asymptotically distribution-free -level tests under the null hypothesis of no causal effect of treatment on time to disease whenever the censoring and failure distributions are conditionally independent given treatment arm. However, our tests remain asymptotically distribution-free -level tests in the presence of informative censoring provided either of our assumptions are true. In contrast, a weighted log-rank test will be an -level test in the presence of informative censoring only if (1) one of our two non-identifiable assumptions hold, and (2) the distribution of time to censoring is the same in the two treatment arms. We also extend our methods to studies of the effect of a treatment on the evolution over time of the mean of a repeated measures outcome, such as CD-4 count.     

Estimation of nonseparable models with censored dependent variables and endogenous regressors

In this article we develop a nonparametric estimator for the local average response of a censored dependent variable to endogenous regressors in a nonseparable model where the unobservable error term is not restricted to be scalar and where the nonseparable function need not be monotone in the unobservables. We formalize the identification argument put forward in Altonji, Ichimura, and Otsu (2012 Altonji, J. G., Ichimura, H., Otsu, T. (2012). Estimating derivatives in nonseparable models with limited dependent variables. Econometrica 80:1701–1719.[Crossref], [Web of Science ®] , [Google Scholar]), construct a nonparametric estimator, characterize its asymptotic property, and conduct a Monte Carlo investigation to study its small sample properties. Identification is constructive and is achieved through a control function approach. We show that the estimator is consistent and asymptotically normally distributed. The Monte Carlo results are encouraging.     

从启蒙者到依附者——“17年诗歌”诗人角色的易换

回望17年诗坛,我们在大多数诗歌千篇一律的声音里发现,那个自"五四"以来就置身于"启蒙"潮头的身影,在三十年后竟然成为政策的传声筒、政治的依附者。社会状况、读者对象、诗歌审美标准、诗人心态的改变,及其病态的"先锋情结",是这代诗人们最终选择"依附者"角色的至关重要的因素。     

Semiparametric regression methods for temporal processes subject to multiple sources of censoring

Process regression methodology is underdeveloped relative to the frequency with which pertinent data arise. In this article, the response-190 is a binary indicator process representing the joint event of being alive and remaining in a specific state. The process is indexed by time (e.g., time since diagnosis) and observed continuously. Data of this sort occur frequently in the study of chronic disease. A general area of application involves a recurrent event with non-negligible duration (e.g., hospitalization and associated length of hospital stay) and subject to a terminating event (e.g., death). We propose a semiparametric multiplicative model for the process version of the probability of being alive and in the (transient) state of interest. Under the proposed methods, the regression parameter is estimated through a procedure that does not require estimating the baseline probability. Unlike the majority of process regression methods, the proposed methods accommodate multiple sources of censoring. In particular, we derive a computationally convenient variant of inverse probability of censoring weighting based on the additive hazards model. We show that the regression parameter estimator is asymptotically normal, and that the baseline probability function estimator converges to a Gaussian process. Simulations demonstrate that our estimators have good finite sample performance. We apply our method to national end-stage liver disease data. The Canadian Journal of Statistics 48: 222–237; 2020 © 2019 Statistical Society of Canada     

Estimation of the joint survival function for successive duration times under double-truncation and right-censoring

ABSTRACT

In incident cohort studies, survival data often include subjects who have had an initiate event at recruitment and may potentially experience two successive events (first and second) during the follow-up period. When disease registries or surveillance systems collect data based on incidence occurring within a specific calendar time interval, the initial event is usually subject to double truncation. Furthermore, since the second duration process is observable only if the first event has occurred, double truncation and dependent censoring arise. In this article, under the two sampling biases with an unspecified distribution of truncation variables, we propose a nonparametric estimator of the joint survival function of two successive duration times using the inverse-probability-weighted (IPW) approach. The consistency of the proposed estimator is established. Based on the estimated marginal survival functions, we also propose a two-stage estimation procedure for estimating the parameters of copula model. The bootstrap method is used to construct confidence interval. Numerical studies demonstrate that the proposed estimation approaches perform well with moderate sample sizes.     

我国“校漂族”研究现状述评

高校的不断扩招,毕业生就业双向选择,"学历社会"的逐步形成,使"校漂族"的人数日渐上升,从而引起了社会各界的广泛关注。文章以1985—2010年在中国期刊网上刊发的关于"校漂族"的所有文章为考察对象,从论文数量、论文级别及学科取向、研究方法、研究内容主题等方面评析了我国"校漂族"研究的总体状况,并指出研究中存在的问题,以期推动该领域的研究。     

Vine copula constructions of higher-dimensional dependent reliability systems

Copulas have proved to be very successful tools for the flexible modeling of dependence. Bivariate copulas have been deeply researched in recent years, while building higher-dimensional copulas is still recognized to be a difficult task. In this paper, we study the higher-dimensional dependent reliability systems using a type of decomposition called “vine,” by which a multivariate distribution can be decomposed into a cascade of bivariate copulas. Some equations of system reliability for parallel, series, and k-out-of-n systems are obtained and then decomposed based on C-vine and D-vine copulas. Finally, a shutdown system is considered to illustrate the results obtained in the paper.     

On the asymptotic normality of the R-estimators of the slope parameters of simple linear regression models with associated errors

ABSTRACT

The purpose of this paper is to prove, under mild conditions, the asymptotic normality of the rank estimator of the slope parameter of a simple linear regression model with stationary associated errors. This result follows from a uniform linearity property for linear rank statistics that we establish under general conditions on the dependence of the errors. We prove also a tightness criterion for weighted empirical process constructed from associated triangular arrays. This criterion is needed for the proofs which are based on that of Koul [Behavior of robust estimators in the regression model with dependent errors. Ann Stat. 1977;5(4):681–699] and of Louhichi [Louhichi S. Weak convergence for empirical processes of associated sequences. Ann Inst Henri Poincaré Probabilités Statist. 2000;36(5):547–567].     

Precise large deviations for φ-mixing and UND random variables with long-tailed distributions

In this paper, we investigate the precise large deviations for sums of φ-mixing and UND random variables with long-tailed distributions. The asymptotic relations for non random sum and random sum of random variables with long-tailed distributions are obtained.