Properties of the weighted log‐rank test in the design of confirmatory studies with delayed effects

Proportional hazards are a common assumption when designing confirmatory clinical trials in oncology. This assumption not only affects the analysis part but also the sample size calculation. The presence of delayed effects causes a change in the hazard ratio while the trial is ongoing since at the beginning we do not observe any difference between treatment arms, and after some unknown time point, the differences between treatment arms will start to appear. Hence, the proportional hazards assumption no longer holds, and both sample size calculation and analysis methods to be used should be reconsidered. The weighted log‐rank test allows a weighting for early, middle, and late differences through the Fleming and Harrington class of weights and is proven to be more efficient when the proportional hazards assumption does not hold. The Fleming and Harrington class of weights, along with the estimated delay, can be incorporated into the sample size calculation in order to maintain the desired power once the treatment arm differences start to appear. In this article, we explore the impact of delayed effects in group sequential and adaptive group sequential designs and make an empirical evaluation in terms of power and type‐I error rate of the of the weighted log‐rank test in a simulated scenario with fixed values of the Fleming and Harrington class of weights. We also give some practical recommendations regarding which methodology should be used in the presence of delayed effects depending on certain characteristics of the trial.     

基于信号博弈的卖方欺诈行为分析

本文主要基于信号博弈的卖方欺诈行为进行研究，假设拍卖中可能存在欺诈型和诚实型两种卖家，其中欺诈行为有概率发生在第二价格拍卖中：欺诈型卖方冒充竞拍者递交仅次于最高价的报价从而获得额外收益。两种卖家根据各自效用选择拍卖形式：第一价格或者第二价格。而竞买者将卖者的选择作为信号，更新对卖方类型的判断，然后制定报价策略。这是一个买卖方信号交叉影响的过程。考虑到拍卖过程中买方价值相关性，本文在建立模型中参考了关联价值原理。针对该模型进行分析，得出了不同情况下的买卖方策略，并且研究了买方报价、买方判断、卖方收益三者之间的关系。文中利用贝叶斯公式对双方的策略选择问题进行预测，与单纯的概率分布方法相比，更具实践价值。     

上证30指数股市盈率实证分析

通过对2000年上证30指数股市盈率水平及其影响因素进行实证分析,可以发现,其中股息支付率、每股收益增长率、行业平均市盈率对股票P/E值起主要的解释作用,而股本规模因素,解释力却有限,除每股收益增长率外,各变量的相关性与理论分析基本一致.     

Measuring agreement between two statistics with applications to age standardization

Summary.  We detail a general method for measuring agreement between two statistics. An application is two ratios of directly standardized rates which differ only by the choice of the standard. If the statistics have a high value for the coefficient of agreement then the expected squared difference between the statistics is small relative to the variance of the average of the two statistics, and inferences vary little by changing statistics. The estimation of a coefficient of agreement between two statistics is not straightforward because there is only one pair of observed values, each statistic calculated from the data. We introduce estimators of the coefficient of agreement for two statistics and discuss their use, especially as applied to functions of standardized rates.     

立足高起点发展新方向培养应用型复合型人才——对我院法学专业教学的认识及建议

我院法学专业培养目标是为社会培养应用型、复合型人才 ,针对实际情况 ,作者提出应改革教学内容 ,优化课程体系 ;改革教学方法 ,完善教学手段 ;提高教师业务水平 ,加强学术梯队建设等建议。     

GPS接收机P(Y)直捕方法研究

GPS接收机P(Y)直捕算法是基于存储的滑动相关搜索,并利用FFT将时频二维联合搜索变成时域一维搜索。同时,考虑位同步点已知的条件,接收资源池只需存储一段接收序列,缩短了捕获时间且利于硬件实现。仿真结果表明,多普勒频移为±5kHz时,所带来的峰值衰减为2dB左右,本地信号与接收信号对齐时出现明显的相关峰,很好地实现了捕获功能;提出了用重叠分段补零FFT操作实现并行相关,成倍降低了捕获时间;提出了利用位同步信息,避免了码极性翻转可能引起的信噪比损耗;针对码相位漂移,提出了优化捕获策略,可在短时间内完成重捕。     

采用二阶特征窗的语音盲分离方法

利用语音信号的短时平稳特性,提出了一种二阶特征窗语音盲分离方法。该方法采用新的联合差分相关矩阵白化算法去除有色噪声影响;用长度等于语音信号基音周期的等距特征窗连续分割预白化观测数据,在每个加窗的数据帧计算不同的时滞协方差矩阵。利用联合近似对角化时滞协方差矩阵集合得到旋转参数,最终达到语音信号的盲分离。该方法消除了有色噪声的影响,只需用到二阶信息就能很好地分离语音信号。仿真实验验证了该方法的有效性。     

两个随机变量的独立性和相关性之比较

从随机变量的独立性和相关性概念出发,运用反例和定理的形式详细探讨二者的区别和联系.     

孔子的富贵观及其现代价值解读

孔子的富贵观是其思想体系的重要组成部分。孔子关于世人应否追求富贵,怎样处理富贵与道义的关系,以及富裕之后还当如何等问题在《论语》中都有论述。孔子的这些论述,对当代人们创业致富,以义求利,以及坚持经济建设与精神文明建设两手抓,仍然具有启迪作用和借鉴价值。     

论审美理念系统的价值阶位

审美理念系统,以其特有的知识形式反映着人类审美价值的阶位需求。文中论述了人类最有代表性的五种阶位需求,认为虽然它们都反映一定的审美本质,但从生命与价值超越角度考虑,它们的内在思想特色和精神追求,还存在着很大的区别。