Properties of the weighted log‐rank test in the design of confirmatory studies with delayed effects

Proportional hazards are a common assumption when designing confirmatory clinical trials in oncology. This assumption not only affects the analysis part but also the sample size calculation. The presence of delayed effects causes a change in the hazard ratio while the trial is ongoing since at the beginning we do not observe any difference between treatment arms, and after some unknown time point, the differences between treatment arms will start to appear. Hence, the proportional hazards assumption no longer holds, and both sample size calculation and analysis methods to be used should be reconsidered. The weighted log‐rank test allows a weighting for early, middle, and late differences through the Fleming and Harrington class of weights and is proven to be more efficient when the proportional hazards assumption does not hold. The Fleming and Harrington class of weights, along with the estimated delay, can be incorporated into the sample size calculation in order to maintain the desired power once the treatment arm differences start to appear. In this article, we explore the impact of delayed effects in group sequential and adaptive group sequential designs and make an empirical evaluation in terms of power and type‐I error rate of the of the weighted log‐rank test in a simulated scenario with fixed values of the Fleming and Harrington class of weights. We also give some practical recommendations regarding which methodology should be used in the presence of delayed effects depending on certain characteristics of the trial.     

LLSM在群体判断中的推广和应用

首先分析了对数最小二乘排序法的特点,说明它是一种值得重视的好方法;并进一步阐述了这一方法的基本原理,着重地对群体判断下求加权的综合排序向量的方法进行了严密的数学推导;提出了在加权的综合排序中权重系数确定的新見解,并举例子以解释。     

Deconvolution with supersmooth distributions

Nonparametric deconvolution problems require one to recover an unknown density when the data are contaminated with errors. Optimal global rates of convergence are found under the weighted L_p-loss (1 ≤ p ≤ ∞). It appears that the optimal rates of convergence are extremely low for supersmooth error distributions. To resolve this difficulty, we examine how high the noise level can be for deconvolution to be feasible, and for the deconvolution estimate to be as good as the ordinary density estimate. It is shown that if the noise level is not too high, nonparametric Gaussian deconvolution can still be practical. Several simulation studies are also presented.     

Modified cross-validation in density estimation

We propose a new modified (biased) cross-validation method for adaptively determining the bandwidth in a nonparametric density estimation setup. It is shown that the method provides consistent minimizers. Some simulation results are reported on which compare the small sample behavior of the new and the classical cross-validation selectors.     

密度分布非均匀的反馈控制Logistic单种群模型平衡态的稳定性

本文对种群密度在非均匀分布情形下,考虑了具反馈控制的滞后 Logistic 生态模型平衡位置的稳定性;分别给出了在常时滞和弱连续时滞以及强连续时滞情况下的稳定性条件;其结果是对 Gopalsamy 在密度均匀分布情形下相应结果的推广.     

Semi-parametric estimation of ROC curves based on binomial regression modelling

This paper presents a method of estimating a receiver operating characteristic (ROC) curve when the underlying diagnostic variable X is continuous and fully observed. The new method is based on modelling the probability of response given X , rather than the distribution of X given response. The method offers advantages in modelling flexibility and computational simplicity. The resulting ROC curve estimates are semi-parametric and can, in principle, take an infinite variety of shapes. Moreover, model selection can be based on standard methods within the binomial regression framework. Statistical accuracy of the curve estimate is provided by a simply implemented bootstrap approach.     

WEIGHTED SUMS OF NEGATIVELY ASSOCIATED RANDOM VARIABLES

In this paper, we establish strong laws for weighted sums of negatively associated (NA) random variables which have a higher‐order moment condition. Some results of Bai Z.D. & Cheng P.E. (2000) [Marcinkiewicz strong laws for linear statistics. Statist. and Probab. Lett. 43, 105–112,] and Sung S.K. (2001) [Strong laws for weighted sums of i.i.d. random variables, Statist. and Probab. Lett. 52, 413–419] are sharpened and extended from the independent identically distributed case to the NA setting. Also, one of the results of Li D.L. et al. (1995) [Complete convergence and almost sure convergence of weighted sums of random variables. J. Theoret. Probab. 8, 49–76,] is complemented and extended.     

一类多元Gauss-Weierstrass算子线性组合的加权逼近

该文给出了一类多元Gauss-Weierstrass算子线性组合加Jacobi权在一致逼近下的正、逆定理和逼近阶的特征刻划