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Exact and Approximate Statistical Inference for Nonlinear Regression and the Estimating Equation Approach
Authors:Eugene Demidenko
Institution:Department of Biomedical Data Science and Department of MathematicsDartmouth College
Abstract:The exact density distribution of the non‐linear least squares estimator in the one‐parameter regression model is derived in closed form and expressed through the cumulative distribution function of the standard normal variable. Several proposals to generalize this result are discussed. The exact density is extended to the estimating equation (EE) approach and the non‐linear regression with an arbitrary number of linear parameters and one intrinsically non‐linear parameter. For a very special non‐linear regression model, the derived density coincides with the distribution of the ratio of two normally distributed random variables previously obtained by Fieler almost a century ago, unlike other approximations previously suggested by other authors. Approximations to the density of the EE estimators are discussed in the multivariate case. Numerical complications associated with the non‐linear least squares are illustrated, such as non‐existence and/or multiple solutions, as major factors contributing to poor density approximation. The non‐linear Markov–Gauss theorem is formulated on the basis of the near exact EE density approximation.
Keywords:Edgeworth approximation  exact statistical inference  Markov theorem  Michaelis–  Menten model  saddlepoint approximation  small‐sample property  partial least squares
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