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A BOOTSTRAP TEST OF THE GOODNESS-OF-FIT OF THE MULTIVARIATE TOLERANCE MODEL
Abstract:The multivariate tolerance (MT) model is used to model multi-agent bioassay survival responses. When the MT model is appropriate, it can aid in identifying the biological mechanism of the survival response or motivate tolerance-based error reduction. A bootstrap test for the goodness-of-fit of the MT model is proposed. The proposed test has little level error, useful power, and makes a novel adjustment for the multiple testing character of the question of MT model goodness-of-fit. This adjustment may be more generally applicable in bootstrap testing.
Keywords:Multi-agent bioassay  Survival response  Synergy  Tolerance-based error reduction  Quantal bioassay
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