Interval estimation of the 90% effective dose: a comparison of bootstrap resampling methods with some large-sample approaches |
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Authors: | Yangxin Huang Simon P J Kirby Peter Harris John C Dearden |
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Abstract: | A number of recent studies have looked at the coverage probabilities of various common parametric methods of interval estimation of the median effective dose (ED 50 ) for a logistic dose-response curve. There has been comparatively little work done on more extreme effective doses. In this paper, the interval estimation of the 90% effective dose (ED 90 ) will be of principal interest. We provide a comparison of four parametric methods of interval construction with four methods based on bootstrap resampling. |
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