Estimation of Acute Toxicity by Fitting a Dose-Time-Response Surface |
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Authors: | Kai Sun Gary F Krause Foster L Mayer Mark R Ellersieck Asit P Basu |
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Institution: | Department of Statistics, Agricultural Experiment Station, The University of Missouri, Columbia, Missouri 65211.;U.S. Environmental Protection Agency, Environmental Research Laboratory, Sabine Island, Gulf Breeze, Florida 32561. |
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Abstract: | In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose-response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species. |
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Keywords: | Acute toxicity dose time-response surface quantitative assessment model software |
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