Sampling based approach for one-hit and multi-hit models in quantal bioassay |
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Authors: | CHU HUI-MAY KUO LYNN |
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Affiliation: | (1) U-120, Department of Statistics, University of Connecticut, Storrs, CT 06269, USA |
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Abstract: | Bayesian methods for estimating the dose response curves with the one-hit model, the gamma multi-hit model, and their modified versions with Abbott's correction are studied. The Gibbs sampling approach with data augmentation and with the Metropolis algorithm is employed to compute the Bayes estimates of the potency curves. In addition, estimation of the relative additional risk and the virtually safe dose is studied. Model selection based on conditional predictive ordinates from cross-validated data is developed. |
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Keywords: | Abbott's correction conditional predictive ordinate low dose extrapolation Markov chain Monte Carlo Metropolis algorithm risk analysis |
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