Association of vitamin D status and the risk of cardiovascular disease as assessed by various cardiovascular risk scoring systems in patients with type 2 diabetes mellitus |
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Authors: | Rıdvan Sivritepe Sema Basat Damla Ortaboz |
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Affiliation: | Department of Internal Medicine, University of Health Sciences Umraniye Education and Research Hospital, Istanbul, Turkey |
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Abstract: | Objective: The aim of the present study was to evaluate the relationship between vitamin D (25[OH]D) status and the risk of cardiovascular disease as assessed by various cardiovascular risk scoring systems such as QRISK2, BNF, ASSING, SCORE, and Framingham in patients with type 2 diabetes mellitus(T2DM).Methods: The study included 108 patients with vitamin D insufficiency (25[OH]D?≥?10–30?ng/mL) and 100 patients with vitamin D deficiency (25[OH]D?10?ng/mL), who were admitted to the diabetes outpatient clinics due to T2DM and who were aged 45–65?years. QRISK2, BNF, ASSING, SCORE, and Framingham were calculated and compared between the two groups.Results: HbA1c levels were significantly higher in patients with vitamin D deficiency. Patients with vitamin D deficiency had significantly higher Framingham risk score (p?.001) and significantly lower BNF score (p?.001), whereas other scores did not significantly differ between the groups. There was a moderate, statistically significant correlation between 25[OH]D levels and Framingham risk score in negative direction (r?=?0.537) and a weak but statistically significant correlation between 25[OH]D levels and BNF score (r?=?0.295). 25[OH]D levels were significantly higher and HbA1c levels were significantly lower in patients with Framingham cardiovascular risk score ≤10%.Conclusion: We found a close relationship with Framingham cardiovascular risk score in diabetic patients with very low serum vitamin D levels. Cardiovascular risk as assessed by the Framingham’s scale increases with decreasing 25[OH]D levels. BNF score was negatively correlated with 25[OH]D levels. |
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Keywords: | Type 2 diabetes mellitus vitamin D deficiency various cardiovascular risk scores BNF score Framingham risk score |
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