Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey |
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Authors: | Chunhua Deng Zhichao Zhang Hongjun Li Peng Bai Xian Cao |
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Institution: | 1. Department of Andrology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;2. Andrology Center, Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing, China;3. Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China;4. Medical Affairs, Merck Sharp &5. Dohme (China) Holding Ltd, Shanghai, China |
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Abstract: | Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events.Methods: Data from 1545 men aged ≥40?years, with testosterone deficiency (TD) (<300?ng/dL) and non-TD (≥300?ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed.Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs.?18.5: OR?=?2.51, 95% CI: 1.19–5.32, p?=?.016), HDL-c (<0.91 vs. ≥0.91: OR?=?1.60, 95% CI: 1.14–2.24, p?=?.006) and diabetes (diabetes vs. non-diabetes: OR?=?1.48, 95% CI: 1.14–1.92, p?=?.004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR?=?0.69, 95% CI: 0.52–0.91, p?=?.009) and smoking (Ever vs. never: OR?=?0.69, 95% CI: 0.51–0.94, p?=?.018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p?=?.04) and angina/angina pectoris (p?=?.001) compared with subjects without these cardiac problems.Conclusion: Low serum testosterone was associated with multiple risk factors for CHD. |
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Keywords: | NHANES testosterone deficiency cardiovascular disease BMI HDL-c CHD |
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