No association of serum PSA with vitamin D or total oxidant-antioxidant capacity in healthy men |
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| Authors: | Burak Toprak Hulya Yalcin Mustafa Yildirim |
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| Institution: | 1. Department of Clinical Biochemistry, Sivas State hospital, Sivas, Turkey;2. Department of Clinical Biochemistry, Tepecik Teaching and Research Hospital, Izmir, Turkey;3. Department of Internal Medicine, Tepecik Teaching and Research Hospital, Izmir, Turkey |
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| Abstract: | Background and aim: Vitamin D deficiency and oxidative stress were suggested to be related to prostate cancer risk. We aimed to investigate the association of serum PSA concentration with vitamin D and total oxidant/antioxidant levels.Materials and methods: A total of 95 healthy men were enrolled for the cross sectional study. Serum PSA, 25(OH)D, serum total oxidant status, and total antioxidant status were measured.Results: Serum PSA was significantly negatively correlated with serum total oxidant status (r=??0.309, p?=?.003) but there was no significant correlation between PSA and 25(OH)D (p?=?.383) or total antioxidant levels (p?=?.233). After adjustment for age BMI and smoking status with multiple regression analysis, there was no significant association between serum PSA and total oxidant status.Conclusion: We find no evidence for an association between PSA and vitamin D levels or serum total oxidant/antioxidant levels. |
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| Keywords: | Vitamin D PSA BMI smoking total oxidant status |
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