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A unified approach to rank tests for mixed models
Institution:1. Department of Statistics, The Pennsylvania State University, State College PA 16802, USA;2. Department of Medical Statistics, University of Göttingen, Humboldt Allee 32, D-37073 Göttingen, Germany;1. Department of Statistics, School of Economics and Wang Yanan Institute for Studies in Economics, Xiamen University, Xiamen, 361005, China;2. Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1;1. Department of Statistics, School of Economics and Wang Yanan Institute for Studies in Economics, Xiamen University, Xiamen, 361005, China;2. Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada;1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;2. Department of Mathematics, Duke University, Durham, NC, USA;3. Department of Statistical Science, Duke University, Durham, NC, USA
Abstract:The nonparametric version of the classical mixed model is considered and the common hypotheses of (parametric) main effects and interactions are reformulated in a nonparametric setup. To test these nonparametric hypotheses, the asymptotic distributions of quadratic forms of rank statistics are derived in a general framework which enables the derivation of the statistics for the nonparametric hypotheses of the fixed treatment effects and interactions in an arbitrary mixed model. The procedures given here are not restricted to semiparametric models or models with additive effects. Moreover, they are robust to outliers since only the ranks of the observations are needed. They are also applicable to pure ordinal data and since no continuity of the distribution functions is assumed, they can also be applied to data with ties. Some approximations for small sample sizes are suggested and analyzed in a simulation study. The application of the statistics and the interpretation of the results is demonstrated in several worked-out examples where some data sets given in the literature are re-analyzed.
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