Joint modeling of censored longitudinal and event time data |
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Authors: | Francis Pike Lisa Weissfeld |
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Institution: | 1. Center for Clinical Research, Investigation, and Systems Modeling of Acute Illness (C.R.I.S.M.A.), University of Pittsburgh Medical Centre , Pittsburgh , PA , USA;2. Department of Biostatistics , University of Pittsburgh Graduate School of Public Health , Pittsburgh , PA , USA |
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Abstract: | Censoring of a longitudinal outcome often occurs when data are collected in a biomedical study and where the interest is in the survival and or longitudinal experiences of a study population. In the setting considered herein, we encountered upper and lower censored data as the result of restrictions imposed on measurements from a kinetic model producing “biologically implausible” kidney clearances. The goal of this paper is to outline the use of a joint model to determine the association between a censored longitudinal outcome and a time to event endpoint. This paper extends Guo and Carlin's 6] paper to accommodate censored longitudinal data, in a commercially available software platform, by linking a mixed effects Tobit model to a suitable parametric survival distribution. Our simulation results showed that our joint Tobit model outperforms a joint model made up of the more naïve or “fill-in” method for the longitudinal component. In this case, the upper and/or lower limits of censoring are replaced by the limit of detection. We illustrated the use of this approach with example data from the hemodialysis (HEMO) study 3] and examined the association between doubly censored kidney clearance values and survival. |
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Keywords: | joint modeling censored data survival analysis with frailty linear mixed effects model time-dependent covariate |
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