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On a variance stabilizing model and its application to genomic data
Authors:Filidor Vilca  Mariana Rodrigues-Motta
Institution:Departamento de Estatística , Universidade Estadual de Campinas , S?o Paulo , Brazil
Abstract:In this paper, we propose a model based on a class of symmetric distributions, which avoids the transformation of data, stabilizes the variance of the observations, and provides robust estimation of parameters and high flexibility for modeling different types of data. Probabilistic and statistical aspects of this new model are developed throughout the article, which include mathematical properties, estimation of parameters and inference. The obtained results are illustrated by means of real genomic data.
Keywords:EM algorithm  Johnson system distributions  maximum-likelihood method  non-normality  normal scale mixture distributions  transformations
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