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Randomized p-values for multiple testing of composite null hypotheses
Authors:Thorsten Dickhaus
Affiliation:Department of Mathematics, Humboldt-University Berlin, Unter den Linden 6, 10099 Berlin, Germany
Abstract:We are considered with the problem of m simultaneous statistical test problems with composite null hypotheses. Usually, marginal p-values are computed under least favorable parameter configurations (LFCs), thus being over-conservative under non-LFCs. Our proposed randomized p-value leads to a tighter exhaustion of the marginal (local) significance level. In turn, it is stochastically larger than the LFC-based p-value under alternatives. While these distributional properties are typically nonsensical for m  =1, the exhaustion of the local significance level is extremely helpful for cases with m>1m>1 in connection with data-adaptive multiple tests as we will demonstrate by considering multiple one-sided tests for Gaussian means.
Keywords:Data-adaptive multiple test   False discovery rate   Family wise error rate   Quantile transformation   Schweder&ndash  Spjø  tvoll estimator   Simultaneous statistical inference
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