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Using explicit clinician preferences in nonrandomized study designs |
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| Institution: | 1. Biometric Research Branch, EPN-8128, National Cancer Institute, Clinical Trials Section, Bethesda, MD 20892, USA;2. Department of Orthodontics, University of the Pacific, San Francisco, CA 94115, USA;3. Departments of Orthodontics, University of the Pacific, San Francisco, CA 94115, USA;4. University of Medicine and Dentistry of New Jersey, Newark, NJ 05103, USA |
| Abstract: | Nonrandomized study designs are proposed that utilize statements by individual clinicians specifying how they would prefer to treat each patient based on the patient's pre-treatment records. Using these stated preferences allows us to eliminate selection biases in an analysis to estimate treatment effects. The analysis of a pilot study using one of the new designs to examine two orthodontic treatments is presented. |
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