| 骨髓基质干细胞复合PLGA支架修复兔关节软骨缺损 |
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| 引用本文： | 刘方红,张秋芳. 骨髓基质干细胞复合PLGA支架修复兔关节软骨缺损[J]. 西南科技大学学报(哲学社会科学版), 2011, 9(4): 5-6 |
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| 作者姓名： | 刘方红 张秋芳 |
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| 作者单位： | 刘方红,LIU Fanghong(武汉大学医学院,430071;湖北医药学院附属人民医院,442000);张秋芳,ZHANG Qiufang(湖北医药学院中药药理实验室,442000) |
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| 摘 要： | 目的探讨骨髓基质干细胞复合PLGA支架对兔关节软骨损伤的修复作用。方法以聚乳酸/聚羟基乙酸共聚物、磷酸三钙制备支架。取新西兰乳兔骨髓分离BMSCs,传代后接种于支架。54只新西兰大白兔,建立膝关节软骨缺损模型,随机分为模型对照组、支架组和支架+BMSCs组。结果光镜示BMSCs在支架内生长良好;膝关节活动度和移植组织的平均厚度与周边正常软骨平均厚度百分比显著高于模型对照组(P<0·01)。结论 PLGA支架复合BMSCs提高了兔关节软骨缺损的修复效果。
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| 关 键 词： | 骨髓基质干细胞 关节软骨 支架 聚乳酸/聚羟基乙酸共聚物 |
Articular cartilage defects repaired with bone marrow stromal cells and PLGA scaffold in rabbits |
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| LIU Fanghong,ZHANG Qiufang. Articular cartilage defects repaired with bone marrow stromal cells and PLGA scaffold in rabbits[J]. Journal of Southwest University of Science and Technology, 2011, 9(4): 5-6 |
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| Authors: | LIU Fanghong ZHANG Qiufang |
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| Affiliation: | LIU Fanghong1,2,ZHANG Qiufang3.1 School of medicine,Wuhan university,Wuhan 430071,China2 people's hospital of Hubei university of medicine,Shiyan 442000,China.3 Laboratory of Chinese herb pharmacology,people's hospital of Hubei university of medicine,China |
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| Abstract: | Objective To explore the preparing methods in vitro and test the clinical applicability of implantation in vivo of bone marrow stromal stem cells(BMSCs)and polylactic-co-glycolic acid(PLGA)scaffold to repair the defects of articular cartilage in rabbits. Methods 54 adult rabbits were divided into 3 groups ramdomly, the carrier scaffold was composed of polylactic-co-glycolic acid(PLGA), tricalcium phosphate(TCP)and other biomaterials.BMSCs was isolated from the bone marrow of femurs of young new Zealand rabb... |
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| Keywords: | Bone marrow stromal stem cells Articular cartilage scaffold Polylactic-co-glycolic acid |
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