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Estimation and Extrapolation of Tumor Probabilities from a Mouse Bioassay with Survival/Sacrifice Components |
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| Authors: | John H Farmer Ralph L Kodell David W Gaylor |
| Institution: | U. S. Department of Health and Human Services, Food and Drug Administration. National Center for Toxicological Research, Jefferson, AR 72079.;Present address: Department of the Army. HQ TCATA, Methodology and Analysis, Fort Hood, TX 76544. |
| Abstract: | A nonparametric estimator of the probability distribution of time-to-tumor is incorporated into an algorithm for calculating linearly extrapolated dosage limits from an animal carcino-genesis bioassay. The procedure is illustrated with tumor data from a mouse bioassay with 2-acetylaminofluorene. Extrapolated dosage limits for an excess risk of 10 |
| Keywords: | time-to-tumor probabilities linearly extrapolated dosage limits effective sample size |