甘肃省不同地区出生缺陷致病因素分析

为提高人口素质,预防出生缺陷的发生。我们根据甘肃地理特点及经济状况,按随机分层整群抽样方法,抽取当地出生的5岁内婴幼儿作为调查对象。以出生缺陷患儿为病例组,以同年、同性别、居住地相近的正常儿作为对照,对其家庭进行调查。结果显示甘肃省不同地区出生缺陷共有的易患因素为:母亲孕早期服药史;母亲孕早期感染史;父亲年龄在35岁以上亦是产生出生缺陷的危险因素。提示实施出生缺陷干预工程应大力进行孕前、孕早健康教育,深化优生指导,以达到降低出生缺陷发生率的目的。

Analysis on risk factors of birth defects different area in Gansu

Objective The purposes of the investigation were to determine the prevalence of birth defects and to examine the risk factors that maybe make this population more susceptible to the development of birth defects so and to supply some core risk factors for the intervention project on birth defects in Gansu province, West China. Method Forty-two communities of four counties were randomly selected by stratification cluster sampling for the survey on the states of economic and geographical features in the province. The case-control study was adopt in which a matches including both case of infant of birth defects and control of two normal infants who had same age, sex and inhabitation. Infants born under five years old were investigated. The parents of these infants were contacted and completed by investigators regarding the prenatal and postnatal history of their child. The total sample was 885 cases. The disease types of birth defects were classed by the diagnosis standardization of congenital anomalies (ICD-9 codes 740-759). Result The risk factors of birth defects in Gansu different area were: infected history in forepart pregnant; dose history in forepart pregnant and history delivery infants of birth defects and father years old is under 35. Conclusion The risk factors of birth defects in Gansu different area were not only same factors but also different factors. To actualize the intervention project on birth defects in Gansu province, should make health education before pregnant and forepart Pregnant,fall prevalence of birth defects.