Efficiency of generalized estimating equations for binary responses |
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Authors: | N Rao Chaganty Harry Joe |
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Institution: | Old Dominion University, Norfolk, USA; University of British Columbia, Vancouver, Canada |
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Abstract: | Summary. Using standard correlation bounds, we show that in generalized estimation equations (GEEs) the so-called 'working correlation matrix' R ( α ) for analysing binary data cannot in general be the true correlation matrix of the data. Methods for estimating the correlation param-eter in current GEE software for binary responses disregard these bounds. To show that the GEE applied on binary data has high efficiency, we use a multivariate binary model so that the covariance matrix from estimating equation theory can be compared with the inverse Fisher information matrix. But R ( α ) should be viewed as the weight matrix, and it should not be confused with the correlation matrix of the binary responses. We also do a comparison with more general weighted estimating equations by using a matrix Cauchy–Schwarz inequality. Our analysis leads to simple rules for the choice of α in an exchangeable or autoregressive AR(1) weight matrix R ( α ), based on the strength of dependence between the binary variables. An example is given to illustrate the assessment of dependence and choice of α . |
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Keywords: | Generalized estimating equations Multivariate binary data Odds ratio Quasi-least squares Repeated measurements |
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