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Most powerful tests for use in matched pair experiments when data may be censored
Abstract:Four distribution-free tests are developed for use in matched pair experiments when data may be censored: a bootstrap based on estimates of the median difference, and three rerandomization tests. The latter include a globally almost most powerful (GAMP) test which uses the original data and two modified Gilbert-Gehan tests which use the ranks. Computation time is reduced by using a binary count to generate subsamples and by restricting subsampling to the uncensored pairs. In Monte Carlo simulations against normal alternatives, mixed normal alternatives, and exponential alternatives, the GAMP test is most powerful with light censoring, the rank test is most powerful with heavy censoring. The bootstrap degenerates to the sign test and is least powerful.
Keywords:Power  permutation tests  censored data  bootstrap  rerandomization  survival
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