An electrophysiological approach to investigations of sensory dysfunction in schizophrenia |
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Authors: | Inga Griskova Sidse M Arnfred |
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Institution: | 1. Department of Biochemistry and Biophysics, Vilnius University, M. Ciurlionio str. 21/27, 03101, Vilnius, Lithuania 2. Department of Psychiatry, Hvidovre Hospital, University Hospital of Copenhagen, Copenhagen, Denmark 3. Department of Electrophysiological Treatment and Investigation Methods, Vilnius Republican Psychiatric Hospital, Vilnius, Lithuania
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Abstract: | Sensory dysfunction has been shown to be a part of the pathophysiology of schizophrenia. Nowadays we have an objective, non-invasive tool with which to measure neural manifestations of sensory dysfunction. Defined as time-locked changes to external stimuli in the EEG, event-related potentials (ERPs) provide an objective index of information processing in the human brain. Importantly, ERPs may be analyzed through a variety of approaches such as conventional ERP analysis, analysis in the time-frequency domain, microstate segmentation and topographical analysis, as well as source localisation analysis. Each of the methods gives distinct information; they also supplement each other. Here, an attempt is made to verify the validity of combining different approaches to study sensory dysfunction in neuropsychiatric disorders. For example, the data from a schizophrenic patient and an age- and sex-matched healthy subject generate a picture of the events which emerges after visual, proprioceptive and simultaneous presentation of stimuli in both modalities. This approach, though time-consuming, allows the visualisation of changes appearing in the malfunctioning brain as compared to the healthy brain. These methods could ultimately lead to a better establishment of one or more endophenotypes for the schizophrenic disorders. They might also serve as a way to track changes in response to various medications and therapies. |
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