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Confidence intervals on intraclass correlation coefficients in a balanced two-factor random design
Authors:Kye Gilder  Naitee Ting  Lili Tian  Joseph C Cappelleri  R Choudary Hanumara
Institution:1. Biogen Idec Inc., San Diego, CA 92122, USA;2. Pfizer Inc., Global Research & Development, New London, CT 06320, USA;3. Department of Biostatistics, School of Public Health and Health Professions, Buffalo, NY 14214-3000, USA;4. Pfizer Inc., Global Research & Development, Groton, CT 06340, USA;5. Department of Computer Science and Statistics, University of Rhode Island, Kingston, RI 02881, USA
Abstract:A modified large-sample (MLS) approach and a generalized confidence interval (GCI) approach are proposed for constructing confidence intervals for intraclass correlation coefficients. Two particular intraclass correlation coefficients are considered in a reliability study. Both subjects and raters are assumed to be random effects in a balanced two-factor design, which includes subject-by-rater interaction. Computer simulation is used to compare the coverage probabilities of the proposed MLS approach (GiTTCH) and GCI approaches with the Leiva and Graybill 1986. Confidence intervals for variance components in the balanced two-way model with interaction. Comm. Statist. Simulation Comput. 15, 301–322] method. The competing approaches are illustrated with data from a gauge repeatability and reproducibility study. The GiTTCH method maintains at least the stated confidence level for interrater reliability. For intrarater reliability, the coverage is accurate in several circumstances but can be liberal in some circumstances. The GCI approach provides reasonable coverage for lower confidence bounds on interrater reliability, but its corresponding upper bounds are too liberal. Regarding intrarater reliability, the GCI approach is not recommended because the lower bound coverage is liberal. Comparing the overall performance of the three methods across a wide array of scenarios, the proposed modified large-sample approach (GiTTCH) provides the most accurate coverage for both interrater and intrarater reliability.
Keywords:62F25  62J10  62K99  62P10
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