Levels of uric acid in erectile dysfunction of different aetiology |
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| Authors: | Alessandra Barassi Massimiliano Marco Corsi Romanelli Raffaele Pezzilli Elena Dozio Clara Anna Linda Damele Liborio Vaccalluzzo |
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| Institution: | 1. Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy;2. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy;3. Unità Operativa Medicina di Laboratorio-1 Patologia Clinica, IRCCS Policlinico San Donato, Milano, Italy;4. Dipartimento di Malattie dell’Apparato Digerente e Medicina Interna, Ospedale Sant’Orsola-Malpighi, Alma Mater Studiorum, Università degli Studi di Bologna, Bologna, Italy;5. Laboratorio Analisi, ASST Santi Paolo e Carlo, Milano, Italy;6. Andrology and IVF Department, Clinica San Carlo, Paderno Dugnano, Italy |
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| Abstract: | Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3–7.5) were significantly higher (p?p?
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| Keywords: | Endothelial dysfunction erectile dysfunction aging and uric acid |
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