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Reference database of hematological parameters for growing and aging rats |
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| Authors: | Wilson Jacob Filho Caio Cezar Lima Marcos Rodolfo Ramos Paunksnis Ariana Aline Silva Mauro Sérgio Perilhão Marina Caldeira |
| Affiliation: | 1. Faculdade de Medicina, Geriatric Department, Universidade de Sao Paulo, Sao Paulo, Brazil;2. Universidade Sao Judas Tadeu, Sao Paulo, Brazil;3. Departamento de Geriatria, USP, S?o Paulo, Brazil |
| Abstract: | The normal hematological values in various phases of the rat life provide a valuable guide to researchers and could be useful for experimental works. However, database information available on the literature are incomplete. Aim: This study aimed to present normal hematological parameters of young and aged rats. Methods: Male and female rats were distributed into seven experimental groups with 1, 2, 3, 6, 12, 18, and 24 months of age. Blood samples taken from the tails were analyzed. Normal hematological values were determined for each age group. Results: Rats showed a progressive weight gain with advancing age, predominantly after 3 months of life. With advancing age, differences were found on hematological parameters: some of them showed a progressive rise with age and others did not. Hemoglobin levels and hematocrit did not change while the number of circulating red blood cells suffered slight increase. Conclusion: The present study determined the normal values for absolute and relative hematological parameters in Wistar rats from 2 to 24 months for male and female rats. The results can be used in studies of effects of aging, feeding, and medications on growing and aging rats. |
| Keywords: | Aging blood sample hematologic parameters Mus muris |