Use of Cohort Information in the Design and Analysis of Case-Control Studies

Abstract.  Four case studies are presented to illustrate how information available on cohort members can be used to inform the control selection in epidemiologic case-control studies. The basic framework is the nested case-control paradigm and accompanying analysis methods. Emphasis is on development of intuition for choosing study design candidates, the form of the estimators, and extensions of the basic theory to solve design and analysis problems.