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Practical guide to sample size calculations: superiority trials
Authors:Laura Flight  Steven A Julious
Institution:Medical Statistics Group, University of Sheffield, Sheffield, UK
Abstract:A sample size justification is a vital part of any investigation. However, estimating the number of participants required to give meaningful results is not always straightforward. A number of components are required to facilitate a suitable sample size calculation. In this paper, the steps for conducting sample size calculations for superiority trials are summarised. Practical advice and examples are provided illustrating how to carry out the calculations by hand and using the app SampSize. Copyright © 2015 John Wiley & Sons, Ltd.
Keywords:sample size  superiority  power  clinical trials
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