|
|||||
|
|
Historical epidemiology of smallpox in Åland,Finland: 1751–1890 |
|
| Authors: | James H Mielke Lynn B Jorde P Gene Trapp Douglas L Anderton Kari Pitkäinen Aldur W Eriksson |
| Institution: | 1. Department of Anthropology, The University of Kansas, 66045, Lawrence, Kansas 2. Samfundet Folkh?lsons Genetiska Institut Populationsgenestiska Avdelningen, P.O.B. 819, SF00101, Helsingfors 10, Finland 3. Department of Human Genetics, University of Utah School of Medicine, 84132, Salt lake City, Utah 4. Department of Sociology, The University of Chicago, 60637, Chicago, Illinois 5. Department of Economic and Social History, University of Helsinki, 00100, Helsinki 10, Finland 6. Antropogenetisch Institut Vrije Universiteit, P.O. Box 7161, 1007MC, Amsterdam, The Netherlands |
| Abstract: | We analyze a 140-year series of smallpox deaths in the Åland Islands, Finland. Vaccination, introduced in 1805, dramatically reduced the annual number of smallpox deaths. It also influenced the age distribution of smallpox deaths, changing smallpox from a childhood disease before 1805 to one which affected both adults and children after 1805. This appears to be due to the fact that Ålanders were usually vaccinated only once during childhood and often lost their immunity during adulthood. Spectral analysis of the prevaccination time series of smallpox deaths demonstrates a strong seven-year periodicity, reflecting the amount of time necessary to build up a cohort of nonimmune individuals. After the introduction of vaccination, the periodicity changes to eight years. The probability that a parish in Åland was affected by a smallpox epidemic is shown to be highly correlated with migration patterns and parish population sizes. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |