Estimation of a relative potency of two preparations with correlated responses

Estimation of a relative potency of two preparations in so-called parallel-line assays is presented. A special type of incomplete Latin square designs where doses of preparations are administered is considered. Testing hypotheses about similarity of preparations and their relative potency in the case of correlated observations are regarded. Confidence interval for the relative potency of preparations is also given. Theoretical considerations are applied to point and interval estimation of potencies of new tuberculins with respect to some international standards tested in experiments on guinea-pigs.