阿托伐他汀对局灶性脑缺血大鼠神经保护作用的研究

目的：探讨阿托伐他汀对局灶性脑缺血大鼠脑组织丙二醛（ MDA）含量的影响。方法选用健康Sprague-Dawley （ SD）大鼠，随机分为阿托伐他汀预处理组、单纯缺血组和假手术组。阿托伐他汀预处理组于术前15天灌胃阿托伐他汀，6mg/（kg· d），然后制备大鼠局灶性脑缺血模型，化学比色法测定脑组织匀浆中MDA含量。结果与假手术组比较，局灶性脑缺血24小时，MDA含量明显升高（P＜0.05）。与单纯缺血组比较，阿托伐他汀预处理组明显降低脑组织匀浆MDA含量（ P＜0.05）。结论阿托伐他汀可以降低局灶性脑缺血大鼠脑组织MDA含量，增强氧自由基清除作用，具有神经保护作用。

The nerve protect effection of Atorvastatin Calcium on focal cerebral ischemia in rats

Objective To explore the effect of atorvastatin calcium on superoxide malondialdehyde （ MDA） content in focal cer-ebral ischemia rats brain.Methods Healthy Sprague-Dawley （ SD） rats were randomly divided into atorvastatin calcium pretreat-ment group , focal cerebral ischemia but without drug administration group and sham-operated group , Administration of atorvastatin calcium at a dose of 6mg.kg-1.d-1（ip） for 15 days before the operation, 24h after the focal cerebral ischemia model ,The neurolog-ical behavior function was evaluated ,and the expression of MDA content was determined in brain tissue of rats.Results Compared with sham-operated group, after focal cerebral ischemia , MDA content increase in brain tissue（P〈0.05）.Compared with the group with focal cerebral ischemia but without drug administration , atorvastatin calcium pretreatment group reduced MDA content in the rats brain（P〈0.05）.Conclusion Atorvastatin calcium can improve nervous behavioral score in the focal cerebral ischemia rats , lower MDA content in brain tissue , increased scavenging effects of oxygen free radical , Atorvastatin calcium has neuroprotective effect against focal cerebral ischemia in rats.