Linear least squares estimates and nonlinear means

The consistency and asymptotic normality of a linear least squares estimate of the form (X'X)^-X'Y when the mean is not Xβ is investigated in this paper. The least squares estimate is a consistent estimate of the best linear approximation of the true mean function for the design chosen. The asymptotic normality of the least squares estimate depends on the design and the asymptotic mean may not be the best linear approximation of the true mean function. Choices of designs which allow large sample inferences to be made about the best linear approximation of the true mean function are discussed.