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A Bayesian criterion for selecting super saturated screening designs
Authors:Daniel Coleman  Yousceek Jeong  Robert W Keener  
Institution:

a Cytokinetics Inc., 280 East Grand Ave, South San Francisco, CA 94080, USA

b Korea Institute for Currency Research, HIT Bldg., 17 Haengdang-Dong, Seoul 133-791, South Korea

c Department of Statistics, University of Michigan, Ann Arbor, MI 48103, USA

Abstract:Super-saturated designs in which the number of factors under investigation exceeds the number of experimental runs have been suggested for screening experiments initiated to identify important factors for future study. Most of the designs suggested in the literature are based on natural but ad hoc criteria. The “average s2” criteria introduced by Booth and Cox (Technometrics 4 (1962) 489) is a popular choice. Here, a decision theoretic approach is pursued leading to an optimality criterion based on misclassification probabilities in a Bayesian model. In certain cases, designs optimal under the average s2 criterion are also optimal for the new criterion. Necessary conditions for this to occur are presented. In addition, the new criterion often provides a strict preference between designs tied under the average s2 criterion, which is advantageous in numerical search as it reduces the number of local minima.
Keywords:
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