T Cell Immunity and Aging |
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Authors: | Koch Sven Dominik Kempf Juergen Pawelec Graham |
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Affiliation: | Center for Medical Research, University of Tuebingen, D-72072 Tuebingen, Germany. sven-dominik.koch@student.uni-tuebingen.de |
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Abstract: | The effect of age on the immune system is generally detrimental and results in "immunosenescence," a poorly-defined state inadequately reflected in clinical data and for which few reliable "biomarkers of aging" are available. The multinational consortium "T-Cell Immunity in Ageing," T-CIA, was set up to examine these issues specifically as applied to T lymphocytes. This Perspective discusses some of the outcomes of a recent conference that considered progress toward resolving these questions in humans. |
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