Modification of shiftwork effects by chemical workplace exposure

Abstract

Possible chronotoxic effects were the reason to study chemical workplace exposure under the special condition of shiftwork. Eight shiftworkers occupationally exposed to acetone vapours and eight controls were investigated during fast-rotated shiftwork. The mean concentration of acetone during the shifts was close to 1000 ppm (2400 mg/m³). Data on well-being and acute symptoms, but not on performance, indicate that the exposure contributed mainly in an additive way to the negative effects of shiftwork. As a consequence, the exposed shiftworkers revealed enhanced impairments during the night-shift.